From: MicroRNA-19a contributes to the epigenetic regulation of tissue factor in diabetes
Characteristics | Low miR-19a | High miR-19a | p value |
---|---|---|---|
miR-19a | 0.620 ± 0.07 | 4.537 ± 0.98 | < 0.0001 |
miR-126 | 2.386 ± 0.31 | 13.26 ± 2.80 | < 0.0001 |
Sex (m/f) | 15/7 | 18/4 | n.s. |
Age (years) | 67 ± 1.7 | 62 ± 1.9 | < 0.05 |
History of stroke (%) | 13.6 | 9.0 | n.s. |
History of MI (%) | 18.1 | 4.5 | n.s. |
CAD (%) | 50.0 | 31.8 | n.s. |
Hypertension (%) | 100 | 100 | n.s. |
PAD (%) | 27.2 | 22.7 | n.s. |
Diabetic neuropathy (%) | 81.8 | 77.2 | n.s. |
Diabetes years | 15 ± 2.3 | 11 ± 2.1 | n.s. |
BMI (kg/m2) | 30.2 ± 1.3 | 34.2 ± 1.7 | n.s. |
CRP (mg/dL) | 0.83 ± 0.2 | 1.0 ± 0.5 | n.s. |
HbA1c (%) | 7.7 ± 0.2 | 8.7 ± 0.3 | n.s. |
HbA1c (mmol/mol) | 61.1 ± 3.1 | 72.3 ± 3.9 | n.s. |
Fasting blood glucose (mg/dL) | 144 ± 12 | 146 ± 6 | n.s. |
ACE-inhibitor (%) | 40.9 | 50.0 | n.s. |
AT II antagonist (%) | 31.8 | 31.8 | n.s. |
Diuretics (%) | 54.5 | 72.7 | n.s. |
Statins (%) | 54.5 | 50.0 | n.s. |
Anti-diabetic drugs: insulin (%) | 72.7 | 68.1 | n.s. |
Metformin (%) | 36.3 | 68.1 | <Â 0.05 |
Sulfonylureas (%) | 27.2 | 4.5 | <Â 0.05 |
Acarbose (%) | 13.0 | 9.0 | n.s. |
Glinides (%) | 4.5 | 13.6 | n.s. |