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Fig. 5 | Cardiovascular Diabetology

Fig. 5

From: MicroRNA-19a contributes to the epigenetic regulation of tissue factor in diabetes

Fig. 5

miR-19a induces endothelial VCAM1 expression, which is counter acted by miR-126. HMEC were cultured overnight and then transfected with a control mimic, miR-19, miR-126, or both miR-19a and miR-126 together. 24 h post transfection the cells were left untreated or stimulated with 10 ng/mL TNF-α. a VCAM1 mRNA expression analysed by real-time PCR. b Representative western blot shows the protein expression of VCAM1 6 h post TNF-α stimulation. Data are represented as mean ± SEM. *p < 0.05, **p < 0.01, $ p < 0.0001 vs. miR-19a TNF-α, § n.s. vs. co miR TNF-α, n ≥ 4

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