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Fig. 4 | Cardiovascular Diabetology

Fig. 4

From: Potential role of insulin receptor isoforms and IGF receptors in plaque instability of human and experimental atherosclerosis

Fig. 4

VSMCs content and apoptosis in atherosclerotic plaques from the 24-week-old experimental model. Representative photomicrographs and quantification of immunofluorescence against α-SMA (a) and of immunohistochemistry against cleaved PARP (b) in aortic roots from 24-week-old Control, ApoE−/− and BATIRKO; ApoE−/− mice. DAPI staining was performed to localize nuclei of cells presented in aortic roots (blue staining). ***p < 0.0005 vs. Control mice; †††p < 0.0005 vs. ApoE−/− mice. C 24 weeks (n = 7); AE 24 weeks (n = 8); B;AE 24 weeks (n = 7). AE ApoE−/−, B;AE BATIRKO; ApoE−/−, C control, DAPI 4′,6-diamidino-2-phenylindole, PARP poly ADP ribose polymerase, α-SMA α-smooth muscle actin

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