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Table 4 Clinical variables of NAFLD patients according to NASH and severity of fibrosis

From: Reactive hyperemia index (RHI) and cognitive performance indexes are associated with histologic markers of liver disease in subjects with non-alcoholic fatty liver disease (NAFLD): a case control study

Variable Subjects with fibrosis 0–1 (n = 43) Subjects with fibrosis ≥ 2 (n = 37) p
Age (years) (mean ± SD) 50.2 ± 11.9 57.8 ± 12.9 0.008
Weight (kg) (mean ± SD) 75.3 ± 14.0 83.2 ± 20.4 0.045
BMI (kg/m2) (mean ± SD) 27.4 ± 5.1 30.3 ± 5.7 0.017
SBP (mm/Hg) (mean ± SD) 117.8 ± 11.7 126.2 ± 14.6 0.006
DBP (mm/Hg) (mean ± SD) 71.9 ± 8.4 73.6 ± 10.8 0.440
Gender M/F 24/19 16/21 0.262
Hypertension (n/%) 11 (25.6) 17 (45.9) 0.057
Diabetes (n/%) 10 (23.3) 21 (56.8) 0.002
dyslipidemia (n/ %) 7 (16.3) 8 (21.6) 0.542
Previous cardiovascular diseases 0 (0) 3 (8.1) 0.057
Previous cerebrovascular events 0 0 /
RHI (mean ± SD) 1.9 ± 0.54 1.8 ± 0.47 0.211
Aix (%) 139.8 ± 29.4 149.7 ± 23.6 0.103
(mean ± SD) 25.8 ± 13.2 31.9 ± 10.4 0.027
PWV (mt/s) (mean ± SD) 10.0 ± 1.9 10.9 ± 2.3 0.043
MMSE (mean ± SD) 27.8 ± 2.2 26.9 ± 2.9 0.131
Liver stiffness, kPa 7.5 ± 3.6 12.6 ± 8.9 0.001
Histology (%)
 Kleiner steatosis grade 0–3
  1 (n/%) 29 (67.4) 7 (18.9)  
  2 (n/%) 7 (16.3) 15 (40.5) < 0.0005
  3 (n/%) 7 (16.3) 15 (40.5)  
 Lobular inflammation grade 0–3
  0 (n/%) 2 (4.6) 0  
  1 (n/%) 36 (83.7) 9 (24.3)  
  2 (n/%) 4 (9.3) 27 (73.0)  < 0.0005
  3 (n/%) 1 (2.3) 1 (2.7)  
 Hepatocellular ballooning (0–2)
  0 (n/%) 21 (48.8) 2 (5.4)  
  1 (n/%) 20 (46.5) 15 (40.5)  < 0.0005
  2 (n/%) 2 (4.6) 20 (54.0)  
  1. Significant p values are indicated in Italics
  2. SBP systolic blood pressure, DBP diastolic blood pressure, BMI body mass index, Aix augmentation index, PWV pulse wave velocity, RHI reactive hyperemia index, MMSE mini-mental state examination, kPa kiloPascal