Skip to main content

Table 4 Clinical variables of NAFLD patients according to NASH and severity of fibrosis

From: Reactive hyperemia index (RHI) and cognitive performance indexes are associated with histologic markers of liver disease in subjects with non-alcoholic fatty liver disease (NAFLD): a case control study

Variable

Subjects with fibrosis 0–1 (n = 43)

Subjects with fibrosis ≥ 2 (n = 37)

p

Age (years) (mean ± SD)

50.2 ± 11.9

57.8 ± 12.9

0.008

Weight (kg) (mean ± SD)

75.3 ± 14.0

83.2 ± 20.4

0.045

BMI (kg/m2) (mean ± SD)

27.4 ± 5.1

30.3 ± 5.7

0.017

SBP (mm/Hg) (mean ± SD)

117.8 ± 11.7

126.2 ± 14.6

0.006

DBP (mm/Hg) (mean ± SD)

71.9 ± 8.4

73.6 ± 10.8

0.440

Gender M/F

24/19

16/21

0.262

Hypertension (n/%)

11 (25.6)

17 (45.9)

0.057

Diabetes (n/%)

10 (23.3)

21 (56.8)

0.002

dyslipidemia (n/ %)

7 (16.3)

8 (21.6)

0.542

Previous cardiovascular diseases

0 (0)

3 (8.1)

0.057

Previous cerebrovascular events

0

0

/

RHI (mean ± SD)

1.9 ± 0.54

1.8 ± 0.47

0.211

Aix (%)

139.8 ± 29.4

149.7 ± 23.6

0.103

(mean ± SD)

25.8 ± 13.2

31.9 ± 10.4

0.027

PWV (mt/s) (mean ± SD)

10.0 ± 1.9

10.9 ± 2.3

0.043

MMSE (mean ± SD)

27.8 ± 2.2

26.9 ± 2.9

0.131

Liver stiffness, kPa

7.5 ± 3.6

12.6 ± 8.9

0.001

Histology (%)

 Kleiner steatosis grade 0–3

  1 (n/%)

29 (67.4)

7 (18.9)

 

  2 (n/%)

7 (16.3)

15 (40.5)

< 0.0005

  3 (n/%)

7 (16.3)

15 (40.5)

 

 Lobular inflammation grade 0–3

  0 (n/%)

2 (4.6)

0

 

  1 (n/%)

36 (83.7)

9 (24.3)

 

  2 (n/%)

4 (9.3)

27 (73.0)

 < 0.0005

  3 (n/%)

1 (2.3)

1 (2.7)

 

 Hepatocellular ballooning (0–2)

  0 (n/%)

21 (48.8)

2 (5.4)

 

  1 (n/%)

20 (46.5)

15 (40.5)

 < 0.0005

  2 (n/%)

2 (4.6)

20 (54.0)

 
  1. Significant p values are indicated in Italics
  2. SBP systolic blood pressure, DBP diastolic blood pressure, BMI body mass index, Aix augmentation index, PWV pulse wave velocity, RHI reactive hyperemia index, MMSE mini-mental state examination, kPa kiloPascal