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Table 3 Clinical variables of NAFLD patients according to NASH presence

From: Reactive hyperemia index (RHI) and cognitive performance indexes are associated with histologic markers of liver disease in subjects with non-alcoholic fatty liver disease (NAFLD): a case control study

Variable No NASH subjects (n = 28) NASH subjects (n = 52) p
Age (years) (mean ± SD) 51.5 ± 12.8 54.9 ± 12.8 0.258
Weight (kg) (mean ± SD) 78.6 ± 19.9 79.3 ± 15.3 0.850
BMI (kg/m2) (mean ± SD) 27.6 ± 6.3 29.3 ± 5.1 0.812
SBP (mm/Hg) (mean ± SD) 120.1 ± 13.1 122.5 ± 14.1 0.443
DBP (mm/Hg) (mean ± SD) 72.3 ± 9.6 72.9 ± 9.6 0.771
Gender M/F 15/13 25/27 0.815
Hypertension (n/%) 8 (28.6) 20 (38.5) 0.464
Diabetes (n/%) 9 (32.1) 22 (42.3) 0.472
Dyslipidaemia (n/%) 4 (14.3) 11 (21.1) 0.557
Previous cardiovascular diseases 0(0) 3 (5.8) 0.309
Previous cerebrovascular events 0 0 /
RHI (mean ± SD) 1.8 ± 0.51 1.9 ± 0.52 0.670
Aix (%) (mean ± SD) 141.1 ± 25.4
26.8 ± 12.3
146.1 ± 28.1
29.6 ± 12.2
0.338
0.429
PWV (mt/s) (mean ± SD) 10.4 ± 1.9 10.4 ± 2.2 0.971
MMSE (mean ± SD) 27.5 ± 2.0 27.3 ± 2.9 0.765
Liver stiffness, kPa 6.7 ± 2.7 11.5 ± 8.0 0.003
Histology (%)
Kleiner steatosis grade 0–3
 1 (n/%) 16 (57.1) 20 (38.5)  
 2 (n/%) 7 (25.0) 15 (28.8) 0.271
 3 (n/%) 5 (17.9) 17 (32.7)  
Lobular inflammation grade 0–3
 0 (n/%) 2 (7.1) 0  
 1 (n/%) 23 (82.1) 22 (42.3)  
 2 (n/%) 2 (7.1) 29 (55.8) < 0.0001
 3 (n/%) 1 (3.6) 1 (1.9)  
Hepatocellular ballooning (0–2)
 0 (n/%) 11 (39.3) 12 (23.1)  
 1 (n/%) 15 (53.6) 20 (38.4) 0.010
 2 (n/%) 2 (7.1) 20 (38.4)  
Stage of fibrosis (0–4)
 0 (n/%) 11 (39.3) 7 (13.5)  
 1 (n/%) 14 (50.0) 11 (21.1)  
 2 (n/%) 3 (10.7) 11 (21.1) < 0.0001
 3 (n/%) 0 17 (32.7)  
 4 (n/%) 0 6 (11.5)  
  1. Significant p values are indicated in Italics
  2. SBP systolic blood pressure, DBP diastolic blood pressure, BMI body mass index, Aix: augmentation index, PWV pulse wave velocity, RHI reactive hyperemia index, MMSE mini-mental state examination, kPa kiloPascal