Table 3 Clinical variables of NAFLD patients according to NASH presence
Variable | No NASH subjects (n = 28) | NASH subjects (n = 52) | p |
|---|---|---|---|
Age (years) (mean ± SD) | 51.5 ± 12.8 | 54.9 ± 12.8 | 0.258 |
Weight (kg) (mean ± SD) | 78.6 ± 19.9 | 79.3 ± 15.3 | 0.850 |
BMI (kg/m2) (mean ± SD) | 27.6 ± 6.3 | 29.3 ± 5.1 | 0.812 |
SBP (mm/Hg) (mean ± SD) | 120.1 ± 13.1 | 122.5 ± 14.1 | 0.443 |
DBP (mm/Hg) (mean ± SD) | 72.3 ± 9.6 | 72.9 ± 9.6 | 0.771 |
Gender M/F | 15/13 | 25/27 | 0.815 |
Hypertension (n/%) | 8 (28.6) | 20 (38.5) | 0.464 |
Diabetes (n/%) | 9 (32.1) | 22 (42.3) | 0.472 |
Dyslipidaemia (n/%) | 4 (14.3) | 11 (21.1) | 0.557 |
Previous cardiovascular diseases | 0(0) | 3 (5.8) | 0.309 |
Previous cerebrovascular events | 0 | 0 | / |
RHI (mean ± SD) | 1.8 ± 0.51 | 1.9 ± 0.52 | 0.670 |
Aix (%) (mean ± SD) | 141.1 ± 25.4 26.8 ± 12.3 | 146.1 ± 28.1 29.6 ± 12.2 | 0.338 0.429 |
PWV (mt/s) (mean ± SD) | 10.4 ± 1.9 | 10.4 ± 2.2 | 0.971 |
MMSE (mean ± SD) | 27.5 ± 2.0 | 27.3 ± 2.9 | 0.765 |
Liver stiffness, kPa | 6.7 ± 2.7 | 11.5 ± 8.0 | 0.003 |
Histology (%) | |||
Kleiner steatosis grade 0–3 | |||
1 (n/%) | 16 (57.1) | 20 (38.5) | |
2 (n/%) | 7 (25.0) | 15 (28.8) | 0.271 |
3 (n/%) | 5 (17.9) | 17 (32.7) | |
Lobular inflammation grade 0–3 | |||
0 (n/%) | 2 (7.1) | 0 | |
1 (n/%) | 23 (82.1) | 22 (42.3) | |
2 (n/%) | 2 (7.1) | 29 (55.8) | < 0.0001 |
3 (n/%) | 1 (3.6) | 1 (1.9) | |
Hepatocellular ballooning (0–2) | |||
0 (n/%) | 11 (39.3) | 12 (23.1) | |
1 (n/%) | 15 (53.6) | 20 (38.4) | 0.010 |
2 (n/%) | 2 (7.1) | 20 (38.4) | |
Stage of fibrosis (0–4) | |||
0 (n/%) | 11 (39.3) | 7 (13.5) | |
1 (n/%) | 14 (50.0) | 11 (21.1) | |
2 (n/%) | 3 (10.7) | 11 (21.1) | < 0.0001 |
3 (n/%) | 0 | 17 (32.7) | |
4 (n/%) | 0 | 6 (11.5) | |