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Table 1 The effect of sitagliptin on the GSM of the carotid wall

From: Effect of sitagliptin on tissue characteristics of the carotid wall in patients with type 2 diabetes: a post hoc sub-analysis of the sitagliptin preventive study of intima-media thickness evaluation (SPIKE)

  n Sitagliptin treatment group n Conventional treatment group Adj. mean difference (95% CI) p value between-group
Mean GSM-CCA (weeks)
 Baseline 137 50.6 ± 18.6 136 52.6 ± 18.3   0.36
 52 130 51.1 ± 17.9 126 52.0 ± 17.6   0.66
 104 120 52.6 ± 16.9 122 53.5 ± 20.3   0.69
Mean change (SE) (weeks)
 52   0.65 (1.11)   0.25 (1.14) 0.40 (− 2.74, 3.53) 0.80
 104   2.40 (1.19)*   1.32 (1.19) 1.08 (− 2.23, 4.39) 0.52
Right GSM-CCA (weeks)
Baseline 136 51.3 ± 20.6 136 52.8 ± 18.9   0.53
 52 129 51.2 ± 19.1 126 53.1 ± 18.8   0.41
 104 120 53.2 ± 18.2 122 53.4 ± 20.6   0.94
Mean change (SE) (weeks)
 52   0.14 (1.30)   1.26 (1.32) − 1.13 (− 4.77, 2.53) 0.54
 104   2.39 (1.38)   0.85 (1.37) 1.53 (− 2.30, 5.36) 0.43
Left GSM-CCA (weeks)
 Baseline 136 49.9 ± 19.9 136 52.5 ± 21.2   0.30
 52 130 50.9 ± 19.4 126 50.9 ± 19.5   0.99
 104 120 51.9 ± 19.0 122 53.6 ± 22.2   0.52
Mean change (SE) (weeks)
 52   1.12 (1.38)   − 0.46 (1.40) 1.58 (− 2.29, 5.45) 0.42
 104   2.08 (1.48)   2.12 (1.48) − 0.04 (− 4.17, 4.09) 0.98
Right GSM-plaque (weeks)
 Baseline 74 51.4 ± 19.5 65 55.8 ± 21.5   0.21
 52 72 51.7 ± 19.3 56 55.6 ± 22.9   0.30
 104 61 53.5 ± 20.4 62 59.2 ± 23.6   0.16
Mean change (SE) (weeks)
 52   2.06 (2.04)   2.80 (2.23) − 0.74 (− 6.77, 5.28) 0.81
 104   5.49 (2.69)*   4.20 (2.71) 1.29 (− 6.30, 8.88) 0.74
Left GSM-plaque (weeks)
 Baseline 80 52.6 ± 23.5 77 55.4 ± 20.9   0.43
 52 76 51.2 ± 19.4 69 54.5 ± 20.5   0.32
 104 73 54.5 ± 21.3 73 51.9 ± 17.5   0.42
Mean change (SE) (weeks)
 52   1.15 (2.19)   − 0.05 (2.24) 1.20 (− 5.01, 7.41) 0.70
 104   5.10 (2.50)*   − 0.35 (2.57) 5.45 (− 1.66, 12.56) 0.13
  1. The primary outcome of this study was the change of Mean GSM-CCA (sown in italics). Data are mean ± SD unless otherwise stated
  2. Comparisons of GSMs during treatment with those at baseline were performed with one-sample t-test based on a mixed-effects model for repeated measures. Differences in Δchange in GSM from baseline at 52 and 104 weeks between groups were analyzed with a mixed-effects model for repeated measures. Treatment group, week, interactions between treatment group and week, and baseline GSM were included as fixed effects
  3. CI confidence interval, GSM gray-scale median, CCA common carotid artery, SE standard error
  4. * p < 0.05