Skip to main content

Table 2 Clinical characteristics of the 935 patients by Hp genotype

From: Mendelian randomization analysis to assess a causal effect of haptoglobin on macroangiopathy in Chinese type 2 diabetes patients

Variable Hp 1-1 Hp 1-2 Hp 2-2 Hp 1-del Hp 2-del Hp del–del P value
N 81 365 414 14 60 1
Age (year) 55.03 ± 11.39 53.16 ± 13.68 51.72 ± 14.58 56.21 ± 16.54 51.72 ± 13.94 52.36 0.1669
Male/female (n) 54/27 216/149 229/185 8/6 43/17 0/1 0.1403
BMI (kg/m2) 25.62 ± 3.53 25.36 ± 3.81 25.46 ± 4.31 26.31 ± 2.85 25.02 ± 4.13 24.84 0.9042
Diastolic blood pressure (mmHg) 80 (70, 90) 80 (75, 85) 80 (72, 85) 78 (74, 82) 80 (74, 84) 70 0.2114
Systolic blood pressure (mmHg) 130 (120, 142) 130 (120, 140) 130 (120, 140) 130 (120, 150) 125 (120, 140) 110 0.0520
Duration of diabetes (years) 10 (4, 14) 8 (4, 12) 8 (3, 13) 9 (5, 12) 10 (1, 14) 7 0.4326
HbA1c (%)
[mmol/mol]
8.3 (6.8, 10.4) [67 (51, 90)] 8.3 (7.2, 10.1) [67 (55, 87)] 8.5 (7.1, 10.2) [69 (54, 88)] 8.1 (7.3, 9.5) [65 (56, 80)] 7.8 (6.9, 10.3) [62 (52, 89)] 6.0 0.9756
HDL-C (mmol/L) 0.96 (0.81, 1.20) 1.00 (0.88, 1.19) 1.00 (0.87, 1.20) 1.05 (0.93, 1.30) 1.08 (0.90, 1.19) 1.30 0.6729
LDL-C (mmol/L) 2.90 (2.20, 3.54) 2.73 (2.10, 3.28) 2.81 (2.23, 3.39) 2.94 (2.35, 3.48) 2.75 (2.01, 3.41) 2.70 0.2549
Total cholesterol (mmol/L) 4.68 (3.80, 5.70) 4.60 (4.00, 5.25) 4.72 (3.97, 5.40) 4.39 (4.20, 5.42) 4.61 (4.01, 5.36) 4.80 0.4200
Triglycerides (mmol/L) 1.40 (1.00, 1.94) 1.47 (0.98, 2.09) 1.47 (1.00, 2.17) 1.53 (1.08, 1.90) 1.47 (0.92, 2.20) 1.00 0.6222
ALT (IU/L) 18 (13, 28) 21 (14, 30) 21 (14, 32) 24 (15, 33) 19 (13, 31) 11 0.4981
AST (IU/L) 18 (15, 23) 18 (15, 24) 18 (15, 24) 21 (18, 33) 18 (13, 22) 14 0.3941
Albumin (g/L) 43 (41, 45) 43 (41, 45) 43 (41, 46) 45 (42, 48) 42 (41, 45) 41 0.6930
HsCRP (mg/L) 0.92 (0.47, 2.65) 0.99 (0.50, 2.23) 1.08 (0.48, 2.53) 1.69 (0.91, 6.13) 0.99 (0.46, 2.29) 0.17 0.5477
Haemoglobin (g/L) 139.14 ± 14.32 141.40 ± 15.43 139.04 ± 15.03 136.93 ± 11.09 140.66 ± 16.06 134 0.1324
Macroangiopathy disease 51 (62.96%) 201 (55.07%) 198 (47.83%) 11 (78.57%) 39 (65.00%) 0 0.0044
  1. Data are shown as n or mean ± standard deviation or median (interquartile range)
  2. Hp haptoglobin, BMI body mass index, HDL-C high-density lipoprotein cholesterol, LDL-C low-density lipoprotein cholesterol, ALT alanine aminotransferase, AST aspartate aminotransferase, hsCRP high sensitive C-reactive protein
  3. P values indicate the significance of differences among common Hp genotypes and clinical traits in subjects without the Hp del allele. P values < 0.05 are shown in italic