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Table 2 Clinical characteristics of the 935 patients by Hp genotype

From: Mendelian randomization analysis to assess a causal effect of haptoglobin on macroangiopathy in Chinese type 2 diabetes patients

Variable

Hp 1-1

Hp 1-2

Hp 2-2

Hp 1-del

Hp 2-del

Hp del–del

P value

N

81

365

414

14

60

1

–

Age (year)

55.03 ± 11.39

53.16 ± 13.68

51.72 ± 14.58

56.21 ± 16.54

51.72 ± 13.94

52.36

0.1669

Male/female (n)

54/27

216/149

229/185

8/6

43/17

0/1

0.1403

BMI (kg/m2)

25.62 ± 3.53

25.36 ± 3.81

25.46 ± 4.31

26.31 ± 2.85

25.02 ± 4.13

24.84

0.9042

Diastolic blood pressure (mmHg)

80 (70, 90)

80 (75, 85)

80 (72, 85)

78 (74, 82)

80 (74, 84)

70

0.2114

Systolic blood pressure (mmHg)

130 (120, 142)

130 (120, 140)

130 (120, 140)

130 (120, 150)

125 (120, 140)

110

0.0520

Duration of diabetes (years)

10 (4, 14)

8 (4, 12)

8 (3, 13)

9 (5, 12)

10 (1, 14)

7

0.4326

HbA1c (%)

[mmol/mol]

8.3 (6.8, 10.4) [67 (51, 90)]

8.3 (7.2, 10.1) [67 (55, 87)]

8.5 (7.1, 10.2) [69 (54, 88)]

8.1 (7.3, 9.5) [65 (56, 80)]

7.8 (6.9, 10.3) [62 (52, 89)]

6.0

0.9756

HDL-C (mmol/L)

0.96 (0.81, 1.20)

1.00 (0.88, 1.19)

1.00 (0.87, 1.20)

1.05 (0.93, 1.30)

1.08 (0.90, 1.19)

1.30

0.6729

LDL-C (mmol/L)

2.90 (2.20, 3.54)

2.73 (2.10, 3.28)

2.81 (2.23, 3.39)

2.94 (2.35, 3.48)

2.75 (2.01, 3.41)

2.70

0.2549

Total cholesterol (mmol/L)

4.68 (3.80, 5.70)

4.60 (4.00, 5.25)

4.72 (3.97, 5.40)

4.39 (4.20, 5.42)

4.61 (4.01, 5.36)

4.80

0.4200

Triglycerides (mmol/L)

1.40 (1.00, 1.94)

1.47 (0.98, 2.09)

1.47 (1.00, 2.17)

1.53 (1.08, 1.90)

1.47 (0.92, 2.20)

1.00

0.6222

ALT (IU/L)

18 (13, 28)

21 (14, 30)

21 (14, 32)

24 (15, 33)

19 (13, 31)

11

0.4981

AST (IU/L)

18 (15, 23)

18 (15, 24)

18 (15, 24)

21 (18, 33)

18 (13, 22)

14

0.3941

Albumin (g/L)

43 (41, 45)

43 (41, 45)

43 (41, 46)

45 (42, 48)

42 (41, 45)

41

0.6930

HsCRP (mg/L)

0.92 (0.47, 2.65)

0.99 (0.50, 2.23)

1.08 (0.48, 2.53)

1.69 (0.91, 6.13)

0.99 (0.46, 2.29)

0.17

0.5477

Haemoglobin (g/L)

139.14 ± 14.32

141.40 ± 15.43

139.04 ± 15.03

136.93 ± 11.09

140.66 ± 16.06

134

0.1324

Macroangiopathy disease

51 (62.96%)

201 (55.07%)

198 (47.83%)

11 (78.57%)

39 (65.00%)

0

0.0044

  1. Data are shown as n or mean ± standard deviation or median (interquartile range)
  2. Hp haptoglobin, BMI body mass index, HDL-C high-density lipoprotein cholesterol, LDL-C low-density lipoprotein cholesterol, ALT alanine aminotransferase, AST aspartate aminotransferase, hsCRP high sensitive C-reactive protein
  3. P values indicate the significance of differences among common Hp genotypes and clinical traits in subjects without the Hp del allele. P values < 0.05 are shown in italic
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Cardiovascular Diabetology

ISSN: 1475-2840