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Table 1 Patient baseline characteristics by HbA1c treatment target

From: Individualised treatment targets in patients with type-2 diabetes and hypertension

HbA1c target ≤ 6.5% N = 2644 > 6.5 to ≤ 7.0% N = 2912 > 7.0 to ≤ 7.5% N = 1135 p value
Age (years) 63.3 ± 11.7 66.2 ± 10.5 66.3 ± 10.9 < 0.0001
Female gender (%) 46.3 45.7 44.2 0.51
Diabetes duration (years) 6.1 ± 5.3 7.4 ± 5.8 7.8 ± 6.0 < 0.0001
Bodyweight (kg) 90.2 ± 18.4 90.3 ± 18.4 91.0 ± 18.9 0.45
Any vascular disease (%)a 31.3 33.4 36.5 < 0.05
Any diabetes related disease (%)b 73.1 80.1 77.4 < 0.0001
Other concomitant disease (%) 41.8 47.1 50.8 < 0.0001
All BG values available (< 6 weeks)c 42.9 48.0 38.0 < 0.0001
Metformin (%) 79.9 81.7 81.2 0.23
Sulfonylurea (%) 15.1 19.1 22.5 < 0.0001
Glucosidase inhibitors (%) 1.0 1.5 1.0 0.18
Glinides (%) 2.4 4.0 5.7 < 0.0001
Glitazones (%) 0.5 0.7 0.3 0.18
DPP4-inhibitor (%) 60.0 66.2 63.9 < 0.0001
GLP1-analogue (%) 4.2 5.8 4.4 < 0.05
SGLT-2-inhibitor (%) 1.7 1.9 2.1 0.68
Any insulin (%) 10.9 18.8 22.2 < 0.0001
≥ 3 oral antidiabetic drugs (%) 7.1 11.8 14.0 < 0.0001
≥ 3 antihypertensive drugs (%) 34.4 37.7 37.2 < 0.05
Any non-severe hypoglycaemia (%)d 4.6 5.9 6.6 < 0.05
Any severe hypoglycaemia (%)e 0.9 0.6 0.3 0.05
PR body weight increase (%) 32.6 35.9 34.7 < 0.01
PR signs of hypoglycaemia (%) 14.9 12.8 14.7 0.66
Mean EQ-5D (mean ± SD) 0.90 ± 0.16 0.88 ± 0.17 0.86 ± 0.18 < 0.0001
Problems with mobility (%) 20.7 28.3 33.0 < 0.0001
Problems with self-care (%) 5.9 10.7 12.9 < 0.0001
Problems with daily activities (%) 15.3 25.4 28.8 < 0.0001
Any pain (%) 41.6 51.4 56.8 < 0.0001
Any anxiety/depression (%) 75.9 72.6 72.2 < 0.01
  1. HbA1c glycated haemoglobin, BG blood glucose, DPP dipeptidyl peptidase, GLP glucagon-like peptide, SGLT sodium-glucose transporter protein, PR patient-reported, EQ-5D EuroQol 5D questionnaire regarding health-related quality of life
  2. aAny of CAD, prior MI, prior PCI, prior CABG, prior stroke, prior diagnosis of HF
  3. bAny of neuropathy, retinopathy, laser coagulation, macular oedema, eye doctor visit, blindness, dialysis, or amputation
  4. cFasting blood glucose, postprandial blood glucose, and HbA1c available
  5. dWithout symptoms, symptoms but without help, with help—but not medical help or hospitalisation
  6. eSymptoms with need for medical help or hospital admission