Table 3 Effect of treatment with liraglutide vs. metformin on arterial stiffness, LV function, and oxidative stress

PWV, m/s

11.8 ± 2.5

10.3 ± 3.3*

0.019

11.2 ± 3

11 ± 3

0.719

AI₇₅, %

18 (− 1 to 31)

13 (− 2 to 31)*

0.032

14 (− 9 to 24)

15 (− 8 to 24)

0.503

GLS, %

− 15.4 ± 3

− 16.6 ± 2.7*

0.043

− 15.5 ± 2.9

− 15.7 ± 3.2

0.721

GLSR, 1/s

0.77 ± 0.2

0.89 ± 0.2*

0.038

0.79 ± 0.3

0.82 ± 0.3

0.212

pTw, deg

15.5 ± 4

13.2 ± 6*

0.029

16.2 ± 5

15.0 ± 6

0.313

pUtw velocity, deg/s

− 97 ± 49

− 112 ± 52*

0.033

− 100 ± 41

− 98 ± 43

0.576

%dpTw–Utw_MVO

31 ± 10

40 ± 14*

0.021

29 ± 18

30 ± 18

0.787

%dpTw–Utw_PEF

43 ± 19

53 ± 22

0.018

45 ± 19

50 ± 16

0.874

E/A

0.92 ± 0.2

0.98 ± 0.3

0.555

0.99 ± 0.3

1.1 ± 0.4

0.679

FMD %

8.9 ± 3

13.2 ± 6*

0.003

8.8 ± 5

11.8 ± 6

0.033

MDA, nM/L

0.92 (0.45–2.45)

0.68 (0.43–2.08)^#

0.006

0.78 (0.55–1.58)

0.86 (0.1–1.88)

0.09

PCs, nmol/mg protein

0.023 (0.011–0.026)

0.013 (0.008–0.017)

0.04

0.015 (0.006–0.019)

0.013 (0.009–0.017)

0.08

NT-proBNP, pg/ml

432 (154–2921)

282 (80–2302)*

0.03

490 (202–2670)

400 (98–2083)

0.08