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Fig. 2 | Cardiovascular Diabetology

Fig. 2

From: Sitagliptin improved glucose assimilation in detriment of fatty-acid utilization in experimental type-II diabetes: role of GLP-1 isoforms in Glut4 receptor trafficking

Fig. 2

Sitagliptin improved myocardial glucose uptake and mitigated myocardial dysfunction in GK rats. a Left, cardiac PET images (sagittal, coronal and axial slices) of [18F]-FDG metabolism in (A) wistar, (B) GK and (C) GK-treated rats. Color scale bars represent the standardized uptake value (SUV) range in the myocardia. Right, quantification of SUV in the animal model. b The left-ventricular posterior wall (LVPW) and inter-ventricular septum (IVS) thicknesses, left-ventricular diastolic and systolic diameters (LVDD and LVSD, respectively), the ejection fraction (EF), deceleration time, and the E/A ratio were measured in the rats. Representative Echo-Doppler images for each group are also shown (top). *p < 0.05 and **p < 0.01 vs. wistar. †p < 0.05 and ††p < 0.01 vs. GK rats. N = 8, each group

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Cardiovascular Diabetology

ISSN: 1475-2840