Table 1 Effect of 4 weeks of linagliptin treatment on body weight, tibia length, and organ weights in klotho (−/−) mice
From: DPP-4 inhibition with linagliptin ameliorates the progression of premature aging in klotho−/− mice
Control (n = 10) | Linagliptin (n = 14) | Statistical significance | |
|---|---|---|---|
Body weight (g) | 9.9 ± 0.3 | 11.1 ± 0.3 | P < 0.01 |
Tibia length (mm) | 15.1 ± 0.2 | 15.3 ± 0.1 | NS |
Cerebrum/TL (mg/mm) | 19.3 ± 0.2 | 19.0 ± 0.2 | NS |
Cerebellum/TL (mg/mm) | 3.6 ± 0.1 | 3.6 ± 0.1 | NS |
Left ventricle/TL (mg/mm) | 2.5 ± 0.1 | 2.6 ± 0.1 | NS |
Right ventricle/TL (mg/mm) | 0.6 ± 0.03 | 0.7 ± 0.04 | NS |
Kidney/TL (mg/mm) | 4.6 ± 0.2 | 5.2 ± 0.2 | P < 0.05 |
Subcutaneous fat/TL (mg/mm) | 2.8 ± 0.6 | 3.9 ± 0.5 | NS |
Visceral fat/TL (mg/mm) | 3.1 ± 0.5 | 4.3 ± 0.7 | NS |
Gastrocnemius muscle/TL (mg/mm) | 2.9 ± 0.1 | 3.4 ± 0.1 | P < 0.01 |