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Table 1 Changes in myocardial ischemic tolerance and cardioprotection in animal models of DM

From: Myocyte membrane and microdomain modifications in diabetes: determinants of ischemic tolerance and cardioprotection

Species—model Duration or age Ischemic tolerance Effect on cardioprotection Ref.
Type 1 DM
 Mouse—STZ 1 week RPostC [109]
2 week IPostC [134]
4–5 week IPostC, ACE inhibition [108]
 Rat—STZ 1 week HOPreC [113]
2 week IPreC [116]
2 week Opioid [107]
2 week Opioid [112]
2 week Opioid [298]
2 week Sevoflurane [106]
4 week Erythropoietin [13]
4 week APN, IPostC [135]
4–5 week IPostC, Sevoflurane [104]
6 week IPreC [133]
6 week IPreC [110]
8 week IPostC [99]
8 week APN, IPostC [135]
8 week IPreC [116]
8 week Adenosine [90]
9 week Sevoflurane [111]
12 week IPostC [121]
Unreported Opioid [103]
 Dog—alloxan/STZ 3 week Isoflurane [101]
3 week IPreC [130]
 Rabbit—alloxan 5–6 week LPreC [102]
TYPE 2 DM
 Mouse—HFD 8 week APN [151]
12 week β3-AR [146]
 Mouse—ob/ob 8–10 week old IPreC [142]
 Mouse—db/db 10–12 week old IPostC [145]
12–14 week old IPostC [134]
Unreported Infra-red light [126]
12 week old Not tested H2S PreC [155]
 Rat—STZ/HFD 6 week S1P [87]
 Rat—HFD 4 week Erythropoietin [13]
8 week Sevoflurane [496]
 Rat—ZDF 12 week old Glutamate [154]
16 week old IPreC [91]
 Rat—ZO 10–12 week old IPreC, Diazoxide, HePreC [141]
 Rat—GK 12 week old PPAR [150]
 Rat—OLETF 25–30 week old Erythropoietin [132]
 Rat—mtFHH 12–14 week old Isoflurane [149]
  1. HFD high fat diet, ZDF Zucker diabetic fatty, ZO Zucker obese, GK Goto-Kakizaki, OLETF Otsuka Long-Evans-Tokushima fatty, mtFHH T2D crossbreed with mtDNA from fawn hooded hypertensive rats, IPreC ischaemic preconditioning, IPostC ischaemic postconditioning, HOPreC hyperoxic preconditioning, HePreC helium preconditioning, LPreC ischaemic late preconditioning, RPreC remote preconditioning, S1P sphingosine-1-phosphate, APN adiponectin, β 3 -AR β3-adrenergic receptor, w weeks