Plaque volume and plaque risk profile in diabetic vs. non-diabetic patients undergoing lipid-lowering therapy: a study based on 3D intravascular ultrasound and virtual histology

Kovarnik, Tomas; Chen, Zhi; Mintz, Gary S.; Wahle, Andreas; Bayerova, Kristyna; Kral, Ales; Chval, Martin; Kopriva, Karel; Lopez, John; Sonka, Milan; Linhart, Ales

doi:10.1186/s12933-017-0637-0

Cardiovascular Diabetology

Table 3 Changes of plaque composition in relative and absolute values

From: Plaque volume and plaque risk profile in diabetic vs. non-diabetic patients undergoing lipid-lowering therapy: a study based on 3D intravascular ultrasound and virtual histology

	DM (17 pts, 192 segments)	non-DM (44 pts, 506 segments)	p
Fibrous tissue BL %	0.55 ± 0.15	0.55 ± 0.19	0.69
Fibrous tissue FU %	0.57 ± 0.12	0.56 ± 0.19	0.7
Δ Fibrous tissue %	0.03 ± 0.14	0.01 ± 0.14	0.32
p value for change between BL and FU	0.02	0.78
Fibrous tissue BL (mm²)	1.80 ± 1.31	2.01 ± 1.41	0.26
Fibrous tissue FU (mm²)	2.00 ± 1.51	1.89 ± 1.41	0.92
Δ Fibrous tissue (mm²)	0.21 ± 0.75	− 0.12 ± 0.60	0.001
p value for change between BL and FU	0.037	0.05
Fibrous-fatty tissue BL %	0.15 ± 0.12	0.14 ± 0.11	0.81
Fibrous-fatty tissue FU %	0.15 ± 0.08	0.14 ± 0.11	0.84
Δ Fibrous-fatty tissue %	0.0 ± 0.13	0.0 ± 0.12	0.71
p value for change between BL and FU	0.83	0.42
Fibrous-fatty tissue BL (mm²)	0.41 ± 0.45	0.52 ± 0.55	0.12
Fibrous-fatty tissue FU (mm²)	0.56 ± 0.62	0.51 ± 0.58	0.86
Δ Fibrous-fatty tissue (mm²)	0.15 ± 0.50	− 0.00 ± 0.49	0.17
p value for change between BL and FU	0.002	0.87
NC BL %	0.18 ± 0.12	0.15 ± 0.15	0.43
NC FU %	0.16 ± 0.07	0.14 ± 0.09	0.17
Δ NC %	− 0.02 ± 0.12	− 0.02 ± 0.1	0.94
p value for change between BL and FU	0.03	0.003
NC BL (mm²)	0.83 ± 1.02	0.68 ± 0.86	0.66
NC FU (mm²)	0.63 ± 0.55	0.53 ± 0.59	0.51
Δ NC (mm²)	− 0.20 ± 0.65	−0.15 ± 0.49	0.9
p value for change between BL and FU	0.001	< 0.001
NC abutting lumen BL (°)	61.36 ± 58.65	54.32 ± 57.43	0.75
NC abutting lumen FU (°)	62.63 ± 53.89	51.05 ± 51.02	0.26
Δ NC abutting lumen (°)	1.27 ± 50.23	− 3.27 ± 41.79	0.41
p value for change between BL and FU	0.79	0.24
DC BL %	0.1 ± 0.09	0.08 ± 0.09	0.26
DC FU %	0.09 ± 0.07	0.08 ± 0.08	0.11
Δ DC %	0.0 ± 0.09	0.0 ± 0.07	0.93
p value for change between BL and FU	0.95	0.99
DC BL (mm²)	0.43 ± 0.55	0.33 ± 0.50	0.37
DC FU (mm²)	0.37 ± 0.39	0.29 ± 0.40	0.26
Δ DC (mm²)	−0.06 ± 0.34	− 0.04 ± 0.24	0.82
p value for change between BL and FU	0.1	0.06

We found higher LAPS at follow-up in diabetics compared to non-diabetics (0.13 ± 1.89 vs. − 0.38 ± 1.8, p = 0.002). DM patients also experienced an increase of LAPS during the study, unlike non-DM patients for which LAPS decreased (0.13 ± 1.79 vs. − 0.23 ± 1.66, p = 0.018)
Italic values indicate significant differences

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