Stabilization | Ischemia | Reperfusion | ||||||||
---|---|---|---|---|---|---|---|---|---|---|
20 min | 1 min | 2 min | 5 min | 10 min | 20 min | 30 min | 60 min | 120 min | ||
RPP (mmHg × min × 100) | ||||||||||
3 mM DM control | 164 ± 18d | – | 7 ± 2 | 12 ± 4 | 20 ± 4 | 26 ± 7 | 33 ± 7 | 46 ± 9 | 82 ± 20 | 60 ± 13c |
3 mM DM IPC | 178 ± 17 | – | 7 ± 2 | 19 ± 6 | 45 ± 15 | 60 ± 18 | 77 ± 15 | 90 ± 22 | 123 ± 19 | 127 ± 17a |
3 mM Non-DM control | 302 ± 24 | – | 4 ± 1 | 9 ± 4 | 30 ± 7 | 31 ± 7 | 73 ± 17 | 86 ± 13 | 106 ± 13 | 85 ± 13 |
3 mM Non-DM IPC | 267 ± 10 | – | 4 ± 1 | 14 ± 10 | 44 ± 17 | 57 ± 9 | 72 ± 5 | 90 ± 7 | 89 ± 8 | 89 ± 12 |
11 mM DM control | 210 ± 34 | – | 27 ± 4 | 21 ± 7 | 45 ± 12 | 20 ± 6 | 39 ± 9 | 91 ± 22 | 109 ± 12 | 87 ± 14 |
11 mM DM IPC | 249 ± 42 | – | 19 ± 5 | 14 ± 2 | 59 ± 9 | 75 ± 18 | 134 ± 21 | 142 ± 23 | 200 ± 19 | 145 ± 14b |
11 mM Non-DM control | 289 ± 32 | – | 18 ± 2 | 18 ± 6 | 36 ± 6 | 31 ± 9 | 42 ± 9 | 72 ± 20 | 93 ± 16 | 86 ± 10 |
11 mM Non-DM IPC | 270 ± 31 | – | 12 ± 4 | 33 ± 15 | 94 ± 30 | 41 ± 14 | 127 ± 24 | 152 ± 28 | 173 ± 27 | 176 ± 27a |
Flow (ml/min) | ||||||||||
3 mM DM Control | 14 ± 1 | – | 16 ± 1 | 15 ± 1 | 14 ± 1 | 16 ± 1 | 17 ± 1 | 16 ± 1 | 14 ± 1 | 13 ± 1 |
3 mM DM IPC | 15 ± 1 | – | 21 ± 1 | 18 ± 2 | 19 ± 1 | 20 ± 1 | 20 ± 1 | 19 ± 2 | 18 ± 2 | 15 ± 1a |
3 mM Non-DM Control | 18 ± 1 | – | 14 ± 1 | 13 ± 1 | 14 ± 1 | 16 ± 1 | 17 ± 1 | 17 ± 1 | 15 ± 1 | 12 ± 2 |
3 mM Non-DM IPC | 15 ± 1 | – | 15 ± 2 | 14 ± 1 | 15 ± 2 | 16 ± 2 | 15 ± 1 | 15 ± 1 | 13 ± 1 | 11 ± 1 |
11 mM DM Control | 16 ± 1 | – | 18 ± 2 | 16 ± 2 | 17 ± 2 | 17 ± 2 | 17 ± 1 | 16 ± 2 | 14 ± 2 | 12 ± 1 |
11 mM DM IPC | 18 ± 1 | – | 22 ± 3 | 19 ± 2 | 20 ± 2 | 20 ± 3 | 20 ± 2 | 20 ± 3 | 19 ± 3 | 15 ± 3 |
11 mM Non-DM Control | 18 ± 1 | – | 15 ± 2 | 13 ± 1 | 14 ± 1 | 15 ± 1 | 14 ± 1 | 13 ± 1 | 13 ± 1 | 10 ± 1 |
11 mM Non-DM IPC | 20 ± 2 | – | 23 ± 1 | 20 ± 1 | 22 ± 1 | 23 ± 1 | 23 ± 1 | 21 ± 1 | 17 ± 2 | 15 ± 1b |