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Table 2 Results from coefficient of variation (CV calculated from confocal micrographs of clots from healthy and diabetes plasma)

From: Substantial fibrin amyloidogenesis in type 2 diabetes assessed using amyloid-selective fluorescent stains

Confocal data analysis
Confocal data: young (n = 17) versus old (= 17) healthy individuals
  Marker Healthy clot CV data (age-controlled for T2D) Healthy young clot CV data P
%; median; STD ThT 1.30 (± 0.61) 1.42 (± 0.64) P = 0.21
Amytracker 480 0.89 (± 0.48) 0.78 (± 1.04) P = 0.08
Amytracker 680 1.30 (± 0.46) 1.34 (± 0.77) P = 0.94
  1. Statistical analysis was performed with the Mann–Whitney U test, using the STATSDIRECT (version 2.8.0) software
Confocal data: Age-controlled healthy individuals (n = 17) versus type 2 diabetes individuals (N = 33)
  Marker Healthy clot CV data (age-controlled) Type 2 diabetes clot CV data P
Median; STD ThT 1.30 (± 0.61) 2.52 (± 1.16) P < 0.0001
Amytracker 480 0.89 (± 0.48) 1.44 (± 0.50) P < 0.0001
Amytracker 680 1.30 (± 0.46) 2.30 (± 0.67) P < 0.0001
  1. Statistical analysis was performed with the Mann–Whitney U test, using the STATSDIRECT (version 2.8.0) software
Confocal data: Treated versus untreated diabetes data (n = 15)
  Marker Untreated T2D T2D plasma treated with 8 ng L−1 LBP and 250 µM ergothioneine P
Median; STD ThT 2.23 (± 1.21) 1.58 (± 0.78) P = 0.0008
Amytracker 480 1.25 (± 0.42) 1.25 (± 0.54) P = 0.37
Amytracker 680 1.91 (± 0.73) 1.37 (± 0.55) P = 0.0009
  1. Statistical analysis was performed with the Mann–Whitney U test, using the STATSDIRECT (version 2.8.0) software
  Marker Untreated T2D T2D plasma treated with 20 ng L−1 LBP and 250 µM ergothioneine P
Median; STD ThT 2.23 (± 1.21) 1.75 (± 0.61) P = 0.007
Amytracker 480 1.25 (± 0.42) 0.90 (± 0.34) P = 0.0001
Amytracker 680 1.91 (± 0.73) 1.50 (± 0.37) P = 0.0002
  1. Statistical analysis was performed with the Mann–Whitney U test, using the STATSDIRECT (version 2.8.0) software
  Marker Untreated T2D T2D plasma treated with 30 ng L−1 LBP P
Median; STD ThT 2.23 (± 1.21) 1.87 (± 0.60) P = 0.033
Amytracker 480 1.25 (± 0.42) 1.45 (± 2.98) P = 0.036
Amytracker 680 1.91 (± 0.73) 1.70 (± 0.60) P = 0.042
  1. Statistical analysis was performed with the Mann–Whitney U test, using the STATSDIRECT (version 2.8.0) software