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Table 1 Clinical characteristics of the study population

From: The effects of vildagliptin compared with metformin on vascular endothelial function and metabolic parameters: a randomized, controlled trial (Sapporo Athero-Incretin Study 3)

Variables

Vilda

High met

p value

(n = 48)

(n = 48)

Age (years)

62 (31 to 74)

60 (20 to 74)

0.50*

Male sex (%)

54.2

64.6

0.43

Body mass index (kg/m2)

25.7 ± 4.1

26.1 ± 4.7

0.59

Flow mediated dilatation (%)

5.5 ± 2.0

6.1 ± 3.0

0.20

FPG (mM/L)

7.8 ± 1.3

8.1 ± 1.3

0.20

Hemoglobin A1c (%)

7.3 (6.6 to 8.4)

7.2 (6.4 to 8.7)

0.23*

SBP (mmHg)

129.0 ± 13.0

126.6 ± 12.2

0.35

DBP (mmHg)

75.0 ± 9.2

75.5 ± 10.2

0.83

LDL-cholesterol (mg/dL)

112.4 ± 30.0

110.6 ± 28.7

0.76

Current smokers (%)

29.2

27.1

0.90

Hypertension (%)

41.7

43.8

0.89

Dyslipidemia (%)

77.1

68.8

0.43

Angiotensin-converting enzyme inhibitors/angiotensin II receptor blockers (%)

31.3

27.1

0.81

Statin (%)

39.6

35.4

0.80

Diabetic nephropathy (%)

20.8

20.8

1.00

Metformin (mg)

559.5 ± 107.8

595.2 ± 122.9

0.16

Sulfonylureas (%)

18.8

27.1

0.65

Glinides (%)

0

0

1.00

  1. FPG fasting blood glucose, SBP systolic blood pressure, DBP diastolic blood pressure
  2. Values are mean ± SD or median (range). p value of Vilda vs. high Met groups
  3. * Mann–Whitney U test was applied to the factors age and HbA1c