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Table 5 Physiological and biochemical parameters of diabetic db/db mice treated with vehicle or liraglutide

From: The role of endothelial nitric oxide in the anti-restenotic effects of liraglutide in a mouse model of restenosis

 

Vehicle

Liraglutide (17 nmol/kg/day)

Number

6

6

Food intake (g/day)

7.6 ± 0.2

6.7 ± 0.3

Water intake (g/dy)

10.2 ± 0.2

9.6 ± 0.2

Initial BW (g)

40.6 ± 0.4

39.5 ± 0.4

Final BW (g)

45.5 ± 0.9

43.9 ± 0.7

BW change (g)

4.9 ± 0.7

4.4 ± 0.7

Heart rate (beats/min)

584 ± 7

624 ± 7*

SBP (mmHg)

135 ± 8

141 ± 3

DBP (mmHg)

76 ± 7

69 ± 6

HbA1c (%)

9.5 ± 0.3

9.1 ± 0.8

FPG (mg/dL)

504 ± 41

390 ± 69

TC (mg/dL)

121 ± 7

126 ± 3

TG (mg/dL)

117 ± 12

105 ± 6

Active GLP-1 (pmol/L)

4.2 ± 1.0

6.8 ± 0.5*

  1. Food and water intake were measured throughout the experimental period. The other parameters were evaluated at the end of the experiment, except for initial BW
  2. * p < 0.05 vs. vehicle