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Table 2 Physiological and biochemical parameters of vehicle- or liraglutide-treated mice with or without N-omega-nitro-l-arginine methyl ester

From: The role of endothelial nitric oxide in the anti-restenotic effects of liraglutide in a mouse model of restenosis

 

Vehicle

Liraglutide (17 nmol/kg/day)

+l-NAME (20 mg/kg/day)

Vehicle

Liraglutide (17 nmol/kg/day)

Number

5

5

5

5

Food intake (g/day)

4.1 ± 0.1

3.6 ± 0.3

3.8 ± 0.1

4.2 ± 0.1

Water intake (g/day)

4.7 ± 0.3

5.3 ± 0.5

4.5 ± 0.1

5.0 ± 0.1

Initial BW (g)

22.4 ± 0.7

23.3 ± 0.2

21.7 ± 0.3

22.0 ± 0.6

Final BW (g)

22.9 ± 0.6

25.3 ± 1.0

22.5 ± 0.1

23.8 ± 0.9

Pulse rate (beats/min)

702 ± 15

712 ± 16

645 ± 30

660 ± 24

SBP (mmHg)

126 ± 3

120 ± 6

143 ± 3*†

130 ± 3

DBP (mmHg)

72 ± 10

71 ± 13

97 ± 10

80 ± 10

HbA1c (%)

4.6 ± 0.1

4.5 ± 0.1

4.7 ± 0

4.7 ± 0.1

FPG (mg/dL)

121 ± 10

117 ± 8

120 ± 12

120 ± 14

TC (mg/dL)

89 ± 2

83 ± 6

90 ± 3

93 ± 2

TG (mg/dL)

49 ± 1

50 ± 4

54 ± 1

57 ± 2

  1. Food and water intake were measured throughout the experimental period. The other parameters were evaluated at the end of the experiment, except for initial BW
  2. l -NAME N-omega-nitro-l-arginine methyl ester
  3. * p < 0.05 vs. vehicle; † p < 0.05 vs. liraglutide