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Table 1 Characteristics of the Casale Monferrato population-based cohort, by BMI and diabetes

From: NTproBNP in insulin-resistance mediated conditions: overweight/obesity, metabolic syndrome and diabetes. The population-based Casale Monferrato Study

 

Non diabetes (n = 1880)

Type 2 diabetes (n = 1364)

BMI < 25 kg/m2 (n = 762)

BMI ≥ 25 kg/m2 (n = 1118)

p value

BMI < 25 kg/m2 (n = 447)

BMI ≥ 25 kg/m2 (n = 917)

p value

Age (years)

60.1 ± 8.3

61.4 ± 8.0

0.0007

64.7 ± 7.7

63.6 ± 8.0

0.01

Body mass index (kg/m2)

22.3 ± 2.0

28.9 ± 3.4

< 0.0001

23.8 ± 1.8

31.3 ± 4.6

< 0.0001

Waist circumference (cm)

80.9 ± 9.3

97.6 ± 9.7

< 0.0001

89.9 ± 10.5

103.2 ± 10.6

< 0.0001

Glucose (mmol/l)

4.99  ± 0.74

5.41  ± 1.18

< 0.0001

9.80 ± 3.31

9.89 ± 3.04

0.60

Total cholesterol (mmol/l)

5.69 ± 0.95

5.69 ± 1.02

0.89

5.60 ± 1.05

5.47 ± 1.03

0.08

LDL cholesterol (mmol/l)

3.29 ± 0.85

3.40 ± 0.90

0.007

3.39 ± 0.90

3.32 ± 0.88

0.24

HDL cholesterol (mmol/l)

1.88 ± 0.46

1.62 ± 0.40

< 0.0001

1.49 ± 0.41

1.34 ± 0.34

< 0.0001

Triglycerides (mmol/l)

1.01 (0.72–1.32)

1.32 (0.94–1.80)

< 0.0001

1.36 (0.94–1.91)

1.59 (1.10–2.15)

< 0.0001

Creatinine (µmol/l)

68.9 (60.1–78.7)

78.7 (64.5–84.9)

< 0.0001

84.9 (62.8–84.9)

72.5 (64.5–84.9)

0.007

CRP mg/l

0.11 (0.06–0.19)

0.22 (0.12–0.39)

< 0.0001

0.22 (0.10–0.48)

0.31 (0.14–0.67)

< 0.0001

Uric acid (µmol/l) mg/dl

269.44 ± 73.16

325.36 ± 80.3

< 0.0001

326.55 ± 146.32

333.68 ± 90.41

0.30

Systolic blood pressure (mmHg)

141.6 ± 20.4

150.1 ± 18.9

< 0.0001

143.3 ± 16.5

146.3 ± 16.1

0.001

Diastolic blood pressure (mmHg)

87.5 ± 10.5

93.0 ± 11.0

< 0.0001

81.2 ± 8.5

83.5 ± 8.2

< 0.0001

Hypertension (%)

479 (62.9%)

951 (85.1%)

< 0.0001

375 (84.6%)

830 (90.5%)

< 0.0001

People treated with

 Diuretics

83 (10.9%)

260 (23.3%)

< 0.001

119 (26.6%)

338 (36.7%)

< 0.001

 ACE-inhibitors

82 (10.8%)

215 (19.2%)

< 0.001

153 (34.2%)

397 (43.3%)

< 0.001

 ARBs

28 (2.3%)

83 (4.1%)

0.008

41 (9.2%)

107 (11.7%)

0.16

 AER (µg/min)

3.4 (2.0–5.1)

4.6 (2.6–6.6)

< 0.0001

11.8 (4.2–23.9)

13.6 (4.5–30.5)

0.16

 Smokers

141 (18.5%)

342 (30.6%)

< 0.0001

113 (25.9%)

303 (34.3%)

< 0.0001

 CVD

23 (3.0%)

82 (7.3%)

< 0.001

90 (20.1%)

203 (22.1%)

0.40

 NTproBNP (pg/ml)

14.6 (5–39.5)

13.4 (5–30.9)

0.13

77.3 (32–164)

62.4 (29–133)

0.006

  1. Data are mean ± standard deviation and geometric means (interquartile range)