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Table 8 Mean (IU/L) ± standard deviation serum amylase and lipase values through Week 156

From: A randomized, placebo-controlled study of the cardiovascular safety of the once-weekly DPP-4 inhibitor omarigliptin in patients with type 2 diabetes mellitus

Week Serum amylase Serum lipase
Omarigliptin
N = 2092
Placebo
N = 2100
Omarigliptin
N = 2092
Placebo
N = 2100
0 66.5 ± 33.3
n = 1465
67.5 ± 39.2
n = 1457
45.1 ± 35.4
n = 1465
45.5 ± 53.5
n = 1457
6 71.3 ± 34.0
n = 1353
66.7 ± 35.1
n = 1338
53.4 ± 45.6
n = 1353
45.1 ± 50.1
n = 1337
12 72.9 ± 35.8
n = 1329
68.1 ± 42.7
n = 1301
56.2 ± 49.9
n = 1329
46.4 ± 41.7
n = 1300
18 71.6 ± 35.3
n = 1314
67.4 ± 35.2
n = 1281
52.1 ± 42.2
n = 1313
45.1 ± 39.0
n = 1280
24 72.0 ± 34.8
n = 1305
67.6 ± 33.4
n = 1296
55.6 ± 52.5
n = 1305
45.5 ± 35.0
n = 1295
32 71.3 ± 33.7
n = 1308
68.1 ± 34.8
n = 1292
51.4 ± 33.2
n = 1308
46.4 ± 42.9
n = 1292
40 70.9 ± 35.4
n = 1289
67.1 ± 33.8
n = 1261
51.3 ± 37.5
n = 1289
43.7 ± 29.3
n = 1261
48 71.6 ± 34.6
n = 1282
67.5 ± 35.9
n = 1235
54.2 ± 54.2
n = 1280
44.6 ± 36.1
n = 1236
54 74.1 ± 52.6
n = 1292
68.2 ± 33.5
n = 1253
56.3 ± 185.2
n = 1291
44.1 ± 37.9
n = 1253
66 72.8 ± 35.8
n = 1263
68.8 ± 42.4
n = 1229
54.3 ± 56.3
n = 1260
44.5 ± 37.1
n = 1229
78 75.1 ± 57.9
n = 1339
67.5 ± 33.9
n = 1297
53.4 ± 50.2
n = 1339
47.2 ± 61.9
n = 1294
90 72.1 ± 38.0
n = 836
69.1 ± 38.8
n = 808
57.4 ± 74.0
n = 835
46.1 ± 40.5
n = 808
104 74.8 ± 85.9
n = 612
68.3 ± 42.1
n = 568
72.3 ± 437.2
n = 611
45.1 ± 32.6
n = 568
116 74.7 ± 38.2
n = 376
65.5 ± 30.8
n = 351
59.0 ± 84.0
n = 376
46.6 ± 54.2
n = 351
128 75.7 ± 36.2
n = 213
64.1 ± 32.7
n = 223
58.4 ± 52.6
n = 213
42.9 ± 24.5
n = 223
142 70.7 ± 30.8
n = 69
71.7 ± 54.2
n = 55
52.8 ± 31.2
n = 69
44.0 ± 25.9
n = 55
156 70.0 ± N/A
n = 1
41.0 ± N/A
n = 1
31.0 ± N/A
n = 1
9.0 ± N/A
n = 1
  1. Measurement of amylase and lipase was added to the protocol after study initiation at the request of several European countries; therefore not all patients had baseline values
  2. Central laboratory normal range: serum amylase = 35–121 U/L; serum lipase = 13–60 U/L