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Table 8 Mean (IU/L) ± standard deviation serum amylase and lipase values through Week 156

From: A randomized, placebo-controlled study of the cardiovascular safety of the once-weekly DPP-4 inhibitor omarigliptin in patients with type 2 diabetes mellitus

Week Serum amylase Serum lipase
Omarigliptin N = 2092 Placebo N = 2100 Omarigliptin N = 2092 Placebo N = 2100
0 66.5 ± 33.3 n = 1465 67.5 ± 39.2 n = 1457 45.1 ± 35.4 n = 1465 45.5 ± 53.5 n = 1457
6 71.3 ± 34.0 n = 1353 66.7 ± 35.1 n = 1338 53.4 ± 45.6 n = 1353 45.1 ± 50.1 n = 1337
12 72.9 ± 35.8 n = 1329 68.1 ± 42.7 n = 1301 56.2 ± 49.9 n = 1329 46.4 ± 41.7 n = 1300
18 71.6 ± 35.3 n = 1314 67.4 ± 35.2 n = 1281 52.1 ± 42.2 n = 1313 45.1 ± 39.0 n = 1280
24 72.0 ± 34.8 n = 1305 67.6 ± 33.4 n = 1296 55.6 ± 52.5 n = 1305 45.5 ± 35.0 n = 1295
32 71.3 ± 33.7 n = 1308 68.1 ± 34.8 n = 1292 51.4 ± 33.2 n = 1308 46.4 ± 42.9 n = 1292
40 70.9 ± 35.4 n = 1289 67.1 ± 33.8 n = 1261 51.3 ± 37.5 n = 1289 43.7 ± 29.3 n = 1261
48 71.6 ± 34.6 n = 1282 67.5 ± 35.9 n = 1235 54.2 ± 54.2 n = 1280 44.6 ± 36.1 n = 1236
54 74.1 ± 52.6 n = 1292 68.2 ± 33.5 n = 1253 56.3 ± 185.2 n = 1291 44.1 ± 37.9 n = 1253
66 72.8 ± 35.8 n = 1263 68.8 ± 42.4 n = 1229 54.3 ± 56.3 n = 1260 44.5 ± 37.1 n = 1229
78 75.1 ± 57.9 n = 1339 67.5 ± 33.9 n = 1297 53.4 ± 50.2 n = 1339 47.2 ± 61.9 n = 1294
90 72.1 ± 38.0 n = 836 69.1 ± 38.8 n = 808 57.4 ± 74.0 n = 835 46.1 ± 40.5 n = 808
104 74.8 ± 85.9 n = 612 68.3 ± 42.1 n = 568 72.3 ± 437.2 n = 611 45.1 ± 32.6 n = 568
116 74.7 ± 38.2 n = 376 65.5 ± 30.8 n = 351 59.0 ± 84.0 n = 376 46.6 ± 54.2 n = 351
128 75.7 ± 36.2 n = 213 64.1 ± 32.7 n = 223 58.4 ± 52.6 n = 213 42.9 ± 24.5 n = 223
142 70.7 ± 30.8 n = 69 71.7 ± 54.2 n = 55 52.8 ± 31.2 n = 69 44.0 ± 25.9 n = 55
156 70.0 ± N/A n = 1 41.0 ± N/A n = 1 31.0 ± N/A n = 1 9.0 ± N/A n = 1
  1. Measurement of amylase and lipase was added to the protocol after study initiation at the request of several European countries; therefore not all patients had baseline values
  2. Central laboratory normal range: serum amylase = 35–121 U/L; serum lipase = 13–60 U/L