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Table 3 Events, crude incidence rates and hazard ratios of events by statin types

From: Effects of background statin therapy on glycemic response and cardiovascular events following initiation of insulin therapy in type 2 diabetes: a large UK cohort study

  None Atorvastatin Simvastatin Rosuvastatin Pravastatin
(N = 2043) (N = 4415) (N = 4462) (N = 713) (N = 1092)
Composite outcomea
 No of events/person-years 217/7032 398/16,840 342/18,287 41/2894 97/4461
 Absolute ratesb (95% CI) 30.9 (27.0–35.3) 23.6 (21.4–26.1) 18.7 (16.8–20.8) 14.2 (10.4–19.2) 21.7 (17.8–26.5)
 HRc (95% CI) 1 (reference) 0.75 (0.64–0.89) 0.59 (0.50–0.70) 0.45 (0.32–0.62) 0.68 (0.54–0.87)
 aHRd (95% CI) 1 (reference) 0.82 (0.68–0.98) 0.67 (0.55–0.82) 0.56 (0.39–0.81) 0.78 (0.60–1.01)
All-cause mortality
 No of events/person-years 177/7098 203/17,229 162/18,710 17/2947 33/4616
 Absolute rates (95% CI) 24.9 (21.5–28.9) 11.8 (10.3–13.5) 8.7 (7.4–10.1) 5.8 (3.6–9.3) 7.1 (5.1–10.1)
 HR (95% CI) 1 (reference) 0.45 (0.37–0.55) 0.32 (0.26–0.40) 0.22 (0.13–0.36) 0.27 (0.19–0.39)
 aHR (95% CI) 1 (reference) 0.61 (0.48–0.78) 0.49 (0.38–0.64) 0.39 (0.22–0.67) 0.39 (0.26–0.60)
Acute myocardial infarction (AMI)
 No of events/person-years 5/7094 26/17,168 21/18,670 2/2948 11/4590
 Absolute rates (95% CI) 0.7 (0.3–1.7) 1.5 (1.0–2.2) 1.1 (0.7–1.7) 0.7 (0.2–2.7) 2.4 (1.3–4.3)
 HR (95% CI) 1 (reference) 2.17 (0.83–5.65) 1.62 (0.61–4.30) 0.98 (0.19–5.03) 3.45 (1.20–9.94)
 aHR (95% CI) 1 (reference) 1.42 (0.53–3.78) 0.88 (0.32–2.40) 0.63 (0.12–3.33) 1.61 (0.54–3.78)
Non-fatal stroke
 No of events/person-years 34/7051 168/16,919 158/18,337 22/2896 53/4489
 Absolute rates (95% CI) 4.8 (3.4–6.7) 9.9 (8.5–11.6) 8.6 (7.4–10.1) 7.6 (5.0–11.5) 11.8 (9.0–15.5)
 HR (95% CI) 1 (reference) 2.07 (1.43–2.99) 1.80 (1.24–2.61) 1.59 (0.93–2.72) 2.47 (1.61–3.80)
 aHR (95% CI) 1 (reference) 1.82 (1.22–2.72) 1.67 (1.11–2.51) 1.64 (0.91–2.94) 2.42 (1.52–3.84)
  1. aComposite outcome is a three-point MACE including all-cause mortality, non-fatal acute myocardial infarction (AMI) and non-fatal stroke
  2. bAbsolute rate at 1000 person-years
  3. cHR (unadjusted hazard ratio)
  4. daHR (adjusted hazard ratio). Adjusted for age, gender, duration of insulin use, albumin, glomerular filtration rate, lipid profile, and coronary heart disease