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Table 2 Events, crude incidence rates and hazard ratios of events in the two treatment groups

From: Effects of background statin therapy on glycemic response and cardiovascular events following initiation of insulin therapy in type 2 diabetes: a large UK cohort study

 

Statin use (N = 10,682)

None (N = 2043)

Composite outcomea

 No of events/person-years

878/42,484

217/7032

 Absolute ratesb (95% CI)

20.7 (19.3–22.1)

30.9 (27.0–35.3)

 HRc (95% CI)

1 (reference)

1.53 (1.32–1.77)

 aHRd (95% CI)

1 (reference)

1.36 (1.15–1.62)

All-cause mortality

 No of events/person-years

415/43,503

177/7098

 Absolute rates (95% CI)

9.5 (8.7–10.5)

24.9 (21.5–28.9)

 HR (95% CI)

1 (reference)

2.61 (2.19–3.12)

 aHR (95% CI)

1 (reference)

1.89 (1.51–2.37)

Acute myocardial infarction (AMI)

 No of events/person-years

60/43,377

5/7094

 Absolute rates (95% CI)

1.4 (1.1–1.8)

0.7 (0.3–1.7)

 HR (95% CI)

1 (reference)

0.50 (0.20–1.25)

 aHR (95% CI)

1 (reference)

0.88 (0.35–2.23)

Non-fatal stroke

 No of events/person-years

401/42,643

34/7051

 Absolute rates (95% CI)

9.4 (8.5–10.4)

4.8 (3.4–6.7)

 HR (95% CI)

1 (reference)

0.51 (0.36–0.72)

 aHR (95% CI)

1 (reference)

0.55 (0.38–0.81)

  1. aComposite outcome is a three-point MACE including all-cause mortality, non-fatal acute myocardial infarction (AMI) and non-fatal stroke
  2. bAbsolute rate at 1000 person-years
  3. cHR (unadjusted hazard ratio)
  4. daHR (adjusted hazard ratio). Adjusted for age, gender, duration of insulin use, albumin, glomerular filtration rate, lipid profile, and coronary heart disease