Selenoprotein S: a therapeutic target for diabetes and macroangiopathy?

Table 1 Association between SELENOS SNPs and the risk of related diseases

No.	Rs number^a	Location	Polymorphism [1/2]	Risk of related diseases	References
1	rs28665122	5′ near gene	G/A	Subclinical CVD in T2DM	[75]
				Intestinal type gastric cancer	[80]
				Non-small cell lung cancer	[84]
				Rheumatoid arthritis	[65]
				Hashimoto’s thyroiditis	[86, 87]
				Preeclampsia	[88]
				Spontaneous preterm birth	[89]
2	rs8025174	5′ near gene	C/A	Coronary heart disease	[72]
3	rs34713741	5′ near gene	C/T	Gastric cancer	[81]
				Colorectal cancer	[82, 83]
4	rs4965814	Intron	T/C	Diabetes	[66]
				Ischemic stroke	[73, 74]
				Subclinical CVD in T2DM	[75]
				CVD in T2DM	[75]
5	rs12917258	Intron	G/C	Subclinical CVD in T2DM	[75]
6	rs2009895	Intron	C/T	Hashimoto’s thyroiditis	[87]
7	rs4965373	3′UTR	G/A	Diabetes	[66]
8	rs9874	3′UTR	T/C	Ischemic stroke	[74]
9	rs28628459	3′UTR	T/C	Subclinical CVD in T2DM	[75]
				CVD in T2DM	[75]
10	rs7178239	3′ near gene	C/G	Ischemic stroke	[72]
				Subclinical CVD in T2DM	[75]
11	rs9806366	3′ near gene	C/T	CVD in T2DM	[75]

CVD cardiovascular disease, T2DM type 2 diabetes mellitus, UTR untranslated region
^aRs numbers are from the PubMed SNP database. 1 = major allele, 2 = minor allele

ISSN: 1475-2840