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Table 3 Multivariable stepwise logistic regression model for presence of PAD

From: Serum high mobility group box-1 and osteoprotegerin levels are associated with peripheral arterial disease and critical limb ischemia in type 2 diabetic subjects

 

Variable OR (95% CI)

P value

Model 1

 Age

1.02 (1.01–1.19)

0.146

 Smoking

36.71 (4.54–179.31)

0.001

 Hypertension

24.91 (5.56–89.65)

<0.001

 Hyperlipidemia

12.54 (2.45–28.34)

0.022

 TC

1.56 (1.06–1.94)

0.034

 HDL-C

0.02 (0.01–0.22)

0.001

 LDL-C

9.43 (1.65–74.34)

0.066

 hsCRP

35.32 (7.45–129.22)

<0.001

 IL-6

6.01 (2.02–16.02)

0.012

Model 2

 Sex

0.15 (0.02–0.94)

0.097

 Age

1.56 (1.15–1.78)

0.164

 Smoking

66.43 (4.21–654.01)

0.012

 Hypertension

41.12 (6.24–189.54)

<0.001

 Hyperlipidemia

8.57 (1.57–49.24)

0.017

 TC

0.05 (0.01–0.43)

0.012

 HDL-C

0.01 (0.00–0.24)

0.001

 LDL-C

13.86 (1.34–153.27)

0.019

 hsCRP

65.89 (8.11–436.53)

<0.001

 IL-6

7.87 (2.47–18.04)

0.008

 HMGB-1

12.32 (3.56–23.54)

0.023

 OPG

3.53 (1.54–6.15)

0.019

  1. Model 1: adjusted for traditional cardiovascular risk factors and established inflammatory cytokines; Model 2: adjusted for the risk factors in model 1 plus HMGB-1 and OPG