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Table 3 Multivariable stepwise logistic regression model for presence of PAD

From: Serum high mobility group box-1 and osteoprotegerin levels are associated with peripheral arterial disease and critical limb ischemia in type 2 diabetic subjects

  Variable OR (95% CI) P value
Model 1
 Age 1.02 (1.01–1.19) 0.146
 Smoking 36.71 (4.54–179.31) 0.001
 Hypertension 24.91 (5.56–89.65) <0.001
 Hyperlipidemia 12.54 (2.45–28.34) 0.022
 TC 1.56 (1.06–1.94) 0.034
 HDL-C 0.02 (0.01–0.22) 0.001
 LDL-C 9.43 (1.65–74.34) 0.066
 hsCRP 35.32 (7.45–129.22) <0.001
 IL-6 6.01 (2.02–16.02) 0.012
Model 2
 Sex 0.15 (0.02–0.94) 0.097
 Age 1.56 (1.15–1.78) 0.164
 Smoking 66.43 (4.21–654.01) 0.012
 Hypertension 41.12 (6.24–189.54) <0.001
 Hyperlipidemia 8.57 (1.57–49.24) 0.017
 TC 0.05 (0.01–0.43) 0.012
 HDL-C 0.01 (0.00–0.24) 0.001
 LDL-C 13.86 (1.34–153.27) 0.019
 hsCRP 65.89 (8.11–436.53) <0.001
 IL-6 7.87 (2.47–18.04) 0.008
 HMGB-1 12.32 (3.56–23.54) 0.023
 OPG 3.53 (1.54–6.15) 0.019
  1. Model 1: adjusted for traditional cardiovascular risk factors and established inflammatory cytokines; Model 2: adjusted for the risk factors in model 1 plus HMGB-1 and OPG