Table 2 Distibution of patients, event rate (per 100 person years) and hazard ratios (HRs) for outcomes during follow-up, according to the history of microvascular or macrovascular disease at baseline
| Â | History of microvascular or macrovascular disease Number of events (event rate) | Microvascular disease alone vs. dual absence | Macrovascular disease alone vs. dual absence | Both micro- and macrovascular disease vs. dual absence | ||||||
|---|---|---|---|---|---|---|---|---|---|---|
Dual absence (n = 6789) | Microvascular alone (n = 761) | Macrovascular alone (n = 3196) | Both (n = 394) | HR (95% CI) | P | HR (95% CI) | P | HR (95% CI) | P | |
All-cause mortality | 1136 (1.9) | 201 (3.3) | 773 (2.9) | 155 (5.3) | 1.43 (1.20 to 1.71) | <0.0001 | 1.43 (1.30 to 1.57) | <0.0001 | 2.01 (1.65 to 2.45) | <0.0001 |
Major macrovascular events | 970 (1.7) | 177 (3.1) | 872 (3.6) | 147 (5.6) | 1.64 (1.37 to 1.97) | <0.0001 | 2.04 (1.86 to 2.25) | <0.0001 | 2.92 (2.40 to 3.55) | <0.0001 |
Cardiovascular death | 396 (0.7) | 98 (1.6) | 406 (1.5) | 88 (3.0) | 1.96 (1.52 to 2.52) | <0.0001 | 2.13 (1.84 to 2.46) | <0.0001 | 3.19 (2.44 to 4.17) | <0.0001 |
Myocardial infarction | 310 (0.5) | 57 (1.0) | 295 (1.1) | 60 (2.2) | 1.68 (1.22 to 2.30) | 0.001 | 1.94 (1.65 to 2.29) | <0.0001 | 3.60 (2.63 to 4.92) | <0.0001 |
Stroke | 446 (0.8) | 67 (1.1) | 402 (1.6) | 53 (1.9) | 1.32 (0.99 to 1.76) | 0.06 | 2.15 (1.87 to 2.47) | <0.0001 | 2.36 (1.71 to 3.25) | <0.0001 |
Major clinical microvascular events | 342 (0.6) | 170 (3.2) | 198 (0.8) | 97 (3.9) | 4.74 (3.86 to 5.82) | <0.0001 | 1.26 (1.06 to 1.51) | 0.01 | 6.30 (4.93 to 8.06) | <0.0001 |
Retinal photocoagulation or blindness | 284 (0.5) | 143 (2.7) | 166 (0.6) | 76 (3.1) | 5.28 (4.25 to 6.56) | <0.0001 | 1.34 (1.10 to 1.63) | 0.003 | 6.98 (5.33 to 9.14) | <0.0001 |
ESRD or renal death | 70 (0.1) | 36 (0.6) | 36 (0.1) | 26 (0.9) | 1.95 (1.12 to 3.37) | 0.02 | 0.91 (0.60 to 1.38) | 0.66 | 2.71 (1.53 to 4.81) | 0.0006 |