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Table 3 Glucose and heart rate variability during 24-h and each time-phase in the miglitol group

From: α-Glucosidase inhibitor miglitol attenuates glucose fluctuation, heart rate variability and sympathetic activity in patients with type 2 diabetes and acute coronary syndrome: a multicenter randomized controlled (MACS) study

Parameters Miglitol-treated (n = 13 in CGM, 17 in Holter ECG)
0700–0700 h (24-h) 0700–1800 h (day-time) 1800–0000 h (night-time) 0000–0700 h (bed-time)
Day 1 Day 2 P value Day 1 Day 2 P value Day 1 Day 2 P value Day 1 Day 2 P value
Mean glucose (mmol/L) 8.66 (2.40) 8.69 (2.62) 0.867 8.55 (3.64) 9.25 (3.29) 0.872 9.24 (3.11) 8.84 (2.40) 0.330 7.29 (1.54) 7.67 (2.10) 0.220
Min glucose (mmol/L) 5.31 (1.93) 6.02 (1.37) 0.025 6.53 (2.22) 6.44 (1.25) 0.832 6.68 (2.32) 6.61 (1.47) 0.868 5.70 (2.02) 6.71 (1.90) 0.024
Max glucose (mmol/L) 12.39 (3.52) 11.87 (3.80) 0.157 11.84 (3.60) 11.30 (3.86) 0.121 11.78 (3.78) 10.73 (3.74) 0.019 8.74 (2.00) 9.08 (2.89) 0.405
∆ glucose (mmol/L) 7.08 (3.07) 5.85 (3.58) 0.004 4.92 (2.41) 4.51 (3.48) 0.450 4.73 (2.50) 3.82 (2.89) 0.019 3.04 (1.69) 2.37 (1.96) 0.192
SD glucose (mmol/L) 1.68 (0.90) 1.42 (1.00) 0.025 1.37 (0.63) 1.26 (0.95) 0.435 1.53 (0.70) 1.15 (0.80) 0.005 0.76 (0.45) 0.54 (0.45) 0.068
CV glucose (%) 18.9 (6.4) 15.6 (7.3) 0.007 16.8 (11.2) 12.8 (6.2) 0.154 17.0 (12.9) 12.5 (13.1) 0.055 13.7 (8.1) 9.8 (8.1) 0.068
Mean HR (beats/min) 71 (6) 71 (8) 0.643 69 (20) 74 (8) 0.893 71 (7) 71 (8) 0.968 66 (7) 66 (7) 0.423
Min HR (beats/min) 59 (7) 59 (7) 0.888 63 (6) 63 (8) 0.521 62 (7) 63 (8) 0.336 60 (7) 59 (7) 0.482
Max HR (beats/min) 96 (12) 95 (13) 0.916 93 (8) 95 (13) 0.461 90 (14) 87 (10) 0.246 86 (9) 83 (12) 0.139
SDNN (ms) 96 (37) 108 (43) 0.028 89 (35) 94 (32) 0.277 87 (36) 96 (38) 0.077 77 (33) 86 (36) 0.120
RMSSD (ms) 70 (30) 80 (35) 0.012 79 (42) 81 (32) 0.285 67 (27) 75 (37) 0.098 65 (24) 73 (36) 0.111
Mean LF/HF 1.09 (0.42) 1.14 (0.45) 0.421 1.05 (0.66) 1.10 (0.56) 0.589 1.04 (0.55) 1.11 (0.57) 0.174 1.08 (0.49) 1.05 (0.57) 0.653
Min LF/HF 0.06 (0.09) 0.08 (0.13) 0.154 0.12 (0.19) 0.12 (0.20) 0.972 0.12 (0.12) 0.14 (0.16) 0.174 0.13 (0.16) 0.15 (0.17) 0.575
Max LF/HF 6.39 (3.09) 5.78 (2.58) 0.469 3.88 (3.03) 4.46 (2.36) 0.446 3.77 (2.50) 4.05 (2.30) 0.641 4.99 (2.50) 4.51 (2.86) 0.535
  1. Values are mean (SD). Abbreviations see Table 2