Circulating sortilin level as a potential biomarker for coronary atherosclerosis and diabetes mellitus

Table 1 Clinical and biochemical characteristics of study participants classified according to coronary artery disease

	Total subjects	CAD (−), n = 116	CAD (+), n = 31	P value	P value*
Age (years)	55.5 ± 11.0	52.9 ± 9.2	65.4 ± 11.8	<0.001	N/a
Men (%)	69.4	66	84	0.052	N/a
Body weight (kg)	65.3 ± 11.0	65.8 ± 11.5	63.3 ± 8.60	0.203	0.886
BMI (kg/m²)	23.9 ± 2.8	24.1 ± 2.9	23.4 ± 2.5	0.213	0.587
SBP (mmHg)	122.2 ± 17.0	120.5 ± 16.4	128.6 ± 18.0	0.019	0.015
DBP (mmHg)	73.7 ± 11.7	74.1 ± 12.2	72.3 ± 9.5	0.438	0.633
Glucose (mg/dl)	107.0 ± 1.4	102.0 ± 30.9	161.0 ± 77.0	<0.001	<0.001
HbA1c (%)	6.2 ± 1.2	6.2 ± 1.4	6.9 ± 1.5	0.004	0.068
TC (mg/dl)	194.0 ± 40.3	202.1 ± 35.3	164.0 ± 43.9	<0.001	<0.001
LDL-C (mg/dl)	110.1 ± 26.8	112.6 ± 26.0	100.6 ± 28.4	0.026	0.097
HDL-C (mg/dl)	49.1 ± 12.3	52.0 ± 11.7	38.1 ± 7.2	<0.001	<0.001
TG (mg/dl)	132.7 ± 66.9	131.9 ± 67.4	135.6 ± 65.9	0.623	0.345
hs-CRP (mg/dl)	0.28 ± 0.71	0.11 ± 0.22	0.87 ± 1.26	<0.001	<0.001
DM (%)	29.3	19.8	64.5	<0.001	N/a
HTN (%)	53.7	43.1	93.5	<0.001	N/a
Dyslipidemia (%)	37.4	28.4	71.0	<0.001	N/a

Data are expressed as mean ± SD, or %. CAD coronary artery disease, DM diabetes mellitus, BMI body mass index, SBP systolic blood pressure, DBP diastolic blood pressure, TC total cholesterol, LDL-C LDL cholesterol, HDL-C HDL cholesterol, TG triglyceride, HTN hypertension
P values for student’s t test or nonparametric t test or Chi square test
* P values for age-adjusted ANCOVA

ISSN: 1475-2840