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Table 7 Adverse events

From: Effectiveness of dapagliflozin on vascular endothelial function and glycemic control in patients with early-stage type 2 diabetes mellitus: DEFENCE study

 

Dapagliflozin group (n = 40)

Metformin group (n = 40)

P value

Any adverse events

6 (15.0)

9 (22.5)

0.57

Hypoglycemia

1 (2.5)

0 (0.0)

1.00

Allergic rhinitis

0 (0.0)

1 (2.5)

1.00

Dry mouth

1 (2.5)

0 (0.0)

1.00

Esophageal varices hemorrhage

1 (2.5)a

0 (0.0)

1.00

Frequent urination

1 (2.5)

0 (0.0)

1.00

Upper respiratory tract infection

0 (0.0)

1 (2.5)

1.00

Interstitial lung disease

1 (2.5)a

0 (0.0)

1.00

Gastroesophageal reflux disease

1 (2.5)

0 (0.0)

1.00

Wound

1 (2.5)

0 (0.0)

1.00

Pharyngitis

0 (0.0)

1 (2.5)

1.00

Dyslipidemia

1 (2.5)

0 (0.0)

1.00

Decrease in appetite

0 (0.0)

1 (2.5)

1.00

Alopecia areata

0 (0.0)

1 (2.5)

1.00

Palpitation

0 (0.0)

1 (2.5)

1.00

Cervical dysplasia

0 (0.0)

1 (2.5)a

1.00

Lung cancer, stage 0

0 (0.0)

1 (2.5)a

1.00

Contusion

0 (0.0)

1 (2.5)

1.00

Diarrhea

0 (0.0)

1 (2.5)

1.00

  1. Data are from treated set population
  2. P values are results by Fisher exact test between groups
  3. aSerious adverse event