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Table 4 Changes in lipid parameters, markers of atherosclerosis, oxidative stress, and blood pressure

From: Effectiveness of dapagliflozin on vascular endothelial function and glycemic control in patients with early-stage type 2 diabetes mellitus: DEFENCE study

Parameters

Dapagliflozin group

Metformin group

P value

Total cholesterol (mg/dL)

 Baseline

201.8 ± 33.1 (35)

194.1 ± 31.9 (34)

0.33

 Week 16

205.3 ± 36.0 (37)

182.2 ± 24.8 (37)

0.002

 Percentage change (%)

2.2 ± 13.4 (35)

−5.4 ± 9.3 (34)

0.008

 P value within group

0.35

0.002

 

HDL cholesterol (mg/dL)

 Baseline

50.9 ± 9.0 (35)

53.4 ± 15.4 (34)

0.42

 Week 16

55.1 ± 9.4 (37)

54.7 ± 15.2 (37)

0.90

 Percentage change (%)

8.1 ± 13.4 (35)

3.4 ± 15.3 (34)

0.18

 P value within group

0.001

0.20

 

LDL cholesterol (mg/dL)

 Baseline

109.6 ± 33.2 (35)

96.1 ± 25.0 (34)

0.06

 Week 16

124.0 ± 33.6 (37)

102.7 ± 26.0 (37)

0.003

 Percentage change (%)

19.1 ± 28.0 (35)

9.7 ± 22.2 (34)

0.13

 P value within group

<0.001

0.016

 

Non-HDL cholesterol (mg/dL)

 Baseline

150.9 ± 32.8 (35)

140.7 ± 35.2 (34)

0.22

 Week 16

150.2 ± 33.1 (37)

127.4 ± 24.7 (37)

0.001

 Percent change (%)

0.9 ± 17.0 (35)

−7.7 ± 12.1 (34)

0.018

 P value within group

0.74

<0.001

 

Triglyceride (mg/dL)

 Baseline

142.8 ± 53.1 (37)

145.2 ± 69.0 (37)

0.87

 Week 16

155.9 ± 81.1 (37)

136.2 ± 62.6 (37)

0.25

 Percentage change (%)

11.3 ± 40.8 (37)

4.2 ± 53.4 (37)

0.53

 P value within group

0.10

0.63

 

Adiponectin (μg/mL)

 Baseline

2.6 ± 1.8 (37)

2.7 ± 1.8 (37)

0.77

 Week 16

2.7 ± 2.2 (37)

2.8 ± 2.0 (37)

0.79

 Change

0.1 ± 0.7 (37)

0.1 ± 0.7 (37)

0.97

 P value within group

0.46

0.41

 

ApoB48 (μg/mL)

 Baseline

4.8 ± 3.0 (37)

3.6 ± 1.9 (37)

0.036

 Week 16

5.1 ± 3.9 (37)

3.1 ± 1.8 (37)

0.008

 Change

0.3 ± 2.8 (37)

−0.4 ± 2.2 (37)

0.23

 P value within group

0.55

0.24

 

Urinary 8-OHdG/creatinine (ng/mg Cre)

 Baseline

4.6 ± 2.4 (36)

4.8 ± 2.0 (36)

0.62

 Week 16

4.0 ± 1.9 (37)

5.8 ± 2.3 (37)

<0.001

 Change

−0.6 ± 1.8 (36)

1.1 ± 2.2 (36)

<0.001

 P value within group

0.047

0.004

 

Systolic blood pressure (mmHg)

 Baseline

129.2 ± 13.7 (37)

130.0 ± 12.4 (37)

0.78

 Week 16

126.4 ± 13.2 (37)

130.3 ± 13.5 (37)

0.21

 Change

−2.8 ± 11.6 (37)

0.3 ± 12.6 (37)

0.27

 P value within group

0.15

0.88

 

Diastolic blood pressure (mmHg)

 Baseline

81.8 ± 9.6 (37)

79.9 ± 8.5 (37)

0.36

 Week 16

80.0 ± 8.1 (37)

79.1 ± 7.5 (37)

0.61

 Change

−1.8 ± 7.8 (37)

−0.8 ± 5.8 (37)

0.52

 P value within group

0.16

0.41

 
  1. Data are mean ± standard deviation (n), or median [first quartile, third quartile] (n). P values show results for comparisons between groups by t test or Wilcoxon rank sum test. P values within groups are results of paired t test
  2. ApoB48 apolipoprotein B48, 8OHdG 8-hydroxy-2′-deoxyguanosin. See Table 1 for other abbreviations
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Cardiovascular Diabetology

ISSN: 1475-2840