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Fig. 3 | Cardiovascular Diabetology

Fig. 3

From: In vivo administration of urolithin A and B prevents the occurrence of cardiac dysfunction in streptozotocin-induced diabetic rats

Fig. 3

Cell mechanics and calcium transients. Representative examples of sarcomere shortening (a) and corresponding calcium transients (b; normalized traces: fold increase) recorded from CTRL, D3, D3-UA and D3-UB ventricular myocytes. In c–h bar graphs means values ± SEM of sarcomere fraction of shortening (FS; c), maximal rate of shortening (−dL/dtmax; d), maximal rate of re-lengthening (+dL/dtmax; e), time to 10, 50 and 90% of total cycle length (TBL10%, TBL50%, and TBL90%; f), calcium transient amplitude expressed as peak fluorescence normalized to baseline fluorescence (f/f0; g), and time constant of the intracellular calcium decay (tau; h), measured in CTRL (66 and 33 cells, for mechanics and calcium transients respectively), D3 (91 and 57 cells), D3-UA (100 and 63 cells), and D3-UB (102 and 42 cells). *p < 0.05 significant differences vs CTRL; # p < 0.05 significant differences vs D3; § p < 0.05 significant differences vs D3-UA (2-factor Nested ANOVA)

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