The effects of basal insulin peglispro vs. insulin glargine on lipoprotein particles by NMR and liver fat content by MRI in patients with diabetes

Table 3 Correlations of change in LFC with change in NMR parameters at 26 Weeks of treatment

	Type 1 diabetes		T2 insulin naïve		T2 basal switch
	Glargine	BIL	Glargine	BIL	Glargine	BIL
	n = 86	n = 163	n = 59	n = 119	n = 74	n = 151
Lipoprotein concentration^a
HDL-P, μmol/L
Total HDL	0.142	0.067	−0.051	0.158	−0.028	−0.072
Large HDL	−0.007	−0.017	−0.163	0.065	−0.114	−0.208
Medium HDL	0.132	0.214	0.050	−0.057	0.184	0.036
Small HDL	0.029	−0.048	−0.001	0.127	−0.101	−0.003
LDL-P, nmol/L
Total LDL	0.088	−0.004	0.236	0.259	−0.106	0.201
IDL	0.163	0.099	0.025	0.389	0.180	0.004
Large LDL	−0.131	0.110	−0.033	−0.097	−0.214	−0.068
Small LDL	0.094	−0.037	0.305	0.235	−0.059	0.275
VLDL-P, nmol/L
Total VLDL	0.171	0.093	0.045	0.318	−0.370	0.003
Large VLDL	0.480*	0.297	0.222	0.172	0.229	0.196
Medium VLDL	0.089	0.010	−0.024	0.186	−0.375	0.018
Small VLDL	0.144	0.079	0.081	0.332	−0.352	−0.057
Lipoprotein size^a
HDL size, nm	0.064	−0.057	−0.239	−0.180	0.047	−0.136
LDL size, nm	−0.173	0.164	−0.016	−0.220	−0.014	−0.216
VLDL size, nm	0.119	0.253	0.365	0.026	0.579*	0.189
Apolipoproteins^a
Apo A1, mg/dL	0.166	0.119	−0.014	0.131	0.017	−0.114
Apo A2, mg/dL	−0.011	0.180	0.184	0.335	0.147	0.124
Apo B100, mg/dL	0.077	0.042	0.161	0.510*	−0.033	0.227
Apo C3, mg/dL	0.403	0.138	0.015	0.393	−0.051	0.127
Other parameters^a
Adiponectin, ng/mL	−0.027	0.217	0.092	0.044	0.154	−0.137
CETP, pmol/mL/min	−0.106	−0.020	0.084	−0.038	−0.228	0.167
CETP, μg/mL	−0.361	−0.082	−0.152	0.041	−0.408	−0.137
Serum CEC, %	0.090	0.088	−0.159	0.118	−0.032	0.008
Free fatty acid, mEq/L	−0.016	0.097	0.322	0.162	0.077	0.147

CEC cholesterol efflux capacity, CETP cholesterol ester transfer protein, HDL-P high density lipoprotein particle, LDL-P low density lipoprotein particle, T2 type 2 diabetes, VLDL-P very low density lipoprotein particle
* p < 0.001 for correlation
^aData are Spearman r correlation coefficients

ISSN: 1475-2840