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Table 4 Univariate and multivariate analysis of predictive factors of the study cohort outcomes

From: Multipolar pacing by cardiac resynchronization therapy with a defibrillators treatment in type 2 diabetes mellitus failing heart patients: impact on responders rate, and clinical outcomes

 

HR

Univariate (95 % CI)

p value

HR

Multivariate (95 % CI)

p value

A. Catheter dislodgments

 Age

0.902

[0.807–1.008]

0.068

0.866

[0.741–1.013]

0.072

 Obesity

1.718

[0.218–3.568]

0.608

   

 Renal dysfunction

1.073

[0.136–4.873]

0.946

   

 NYHA 3

0.417

[0.108–1.612]

0.205

   

 QRS duration

0.962

[0.872–1.061]

0.437

   

 LVEF

1.072

[0.928–1.237]

0.345

   

 Quadripolar LV

5.278

[1.175–7.32]

0.035*

0.112

[0.014–0.893]

0.039*

B. Phrenic nerve stimulation

 Age

1.024

[0.962–1.089]

0.458

   

 Obesity

2.604

[0.773–8.767]

0.122

0.658

[0.144–3.01]

0.59

 Renal dysfunction

0.043

[0.02–1.79]

0.306

   

 NYHA 3

2.94

[2.6–4.9]

0.001*

0.97

[0.022–0.423]

0.2

 QRS duration

1.019

[0.975–1.065]

0.405

   

 LVEF

1.012

[0.93–1.101]

0.79

   

 Quadripolar LV

3.783

[1.404–10.191]

0.008*

0.246

[0.088–0.686]

0.007*

C. Re-intervention for catheter dislodgments

 Age

0.902

[0.807–1.008]

0.068

0.866

[0.741–1.013]

0.072

 Obesity

1.718

[0.218–3.568]

    

 Renal dysfunction

1.073

[0.136–4.873]

    

 NYHA 3

0.417

[0.108–1.612]

    

 QRS duration

0.962

[0.872–1.061]

    

 LVEF

1.072

[0.928–1.237]

    

 Quadripolar LV

5.278

[1.175–7.32]

0.035*

0.112

[0.014–0.893]

0.039*

D. Hospital admission for heart failure worsening

 Age

0.823

[0.961–1.051]

0.823

   

 Obesity

1.062

[0.33–3.419]

0.92

   

 Renal  dysfunction

0.898

[0.322–2.501]

0.836

   

 NYHA 3

1.667

[0.926–3.01]

0.089

0.624

[0.326–1.193]

0.154

 QRS duration

1.019

[0.983–1.056]

0.3

1.012

[0.973–1.052]

0.559

 LVEF

0.98

[0.926–1.038]

    

 Quadripolar LV

1.683

[1.04–3.03]

0.05

0.516

[0.279–0. 955]

0.035*

E. Atrial fibrillation events

 Age

1.031

[0.968–1.099]

0.343

   

 Obesity

5.571

[2.038–15.232]

0.001*

1.36

[1.09–1.88]

0.02*

 Renal dysfunction

0.992

[0.231–4.257]

0.991

   

 NYHA 3

2.58

[1.001–6.649]

0.05*

0.557

[0.195–1.591]

0.274

 QRS duration

1.018

[0.971–1.067]

0.457

   

 LVEF

1.043

[0.95–1.146]

0.375

   

 Quadripolar LV

3.29

[1.205–8.982]

0.02*

0.261

[0.086–0.794]

0.018*

F. All cause deaths

 Age

1.138

[1.04–1.246]

0.05*

1.149

[0.89–1.288]

0.058

 Obesity

2.5

[0.9–2.91]

0.986

   

 Renal dysfunction

0.88

[0.108–7.193]

0.905

   

 NYHA 3

1.471

[0.276–7.759]

0.649

   

 QRS duration

1.051

[0.984–1.123]

0.141

   

 LVEF

1.069

[0.914–1.249]

0.404

   

 Quadripolar LV

0.415

[0.104–1.659]

0.214

   

G. Cardiac deaths

 Age

1.3

[1.185–1.426]

0.01*

1.332

[0.858–1.532]

0.056

 Obesity

0.7

[0.2–2.896]

0.168

   

 Renal dysfunction

1.676

[0.2–14.02]

0.633

   

 NYHA 3

0.386

[0.069–2.164]

0.279

   

 QRS duration

0.932

[0.806–1.078]

0.342

   

 LVEF

0.912

[0.815–1.044]

0.201

   

 Quadripolar LV

0.521

[0.154–1.758]

0.293

   
  1. In this table the representation of study outcomes, as catheter dislodgments (A), phrenic nerve stimulation events (B), re-intervention for catheter dislodgments (C), hospital admissions for heart failure worsening (D), atrial fibrillation events (E), all cause deaths (F), and cardiac deaths (G), and multivariate predictive factors
  2. We have used for statistical analysis, a 95% interval of confidence (IC), and a significant statistical p value, p < 0.05. The symbol * was marking factor with a p value <0.05. To test the final statistical used model, we have performed the Hosmer and Lemeshow test, with a χ² = 2.775, and a p value <0.05
  3. NYHA 3 New York Heart Association third class, LVEF left ventricle ejection fraction, LV left ventricle
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Cardiovascular Diabetology

ISSN: 1475-2840