Fig. 1

Study design. EOT end of treatment, LLT lipid-lowering therapy, MTD maximally tolerated dose, non-HDL-C non-high-density lipoprotein cholesterol, Q2W every 2 weeks, R randomisation, W week. ^aFirst study drug administration. As a principle, randomisation should occur after signature of the informed consent form and just before the first dosing of the study drug (i.e. alirocumab or usual care). The randomisation day is always day 1. Randomisation was stratified by the investigator’s selection of usual care therapy prior to randomisation. Phone call visits are indicated in italics