Fig. 4
From: SGLT2 inhibitors: a novel choice for the combination therapy in diabetic kidney disease
Illustration of potential synergistic effects of SGLT2 inhibitor with GLP-1 receptor agonists in DKD therapy. SGLT2i Sodium–glucose co-transporter 2 inhibitor, GLP1-RA glucagon-like peptide-1 receptor agonist, UGE urinary glucose excretion, NF-κB nuclear factor kappa B, MCP-1 monocyte chemoattractant protein-1, GLP-1 glucagon-like peptide-1, SBP systolic blood pressure, eGFR estimated glomerular filtration rate, HDL-C high density lipoprotein-cholesterol, LDL-C low density lipoprotein-cholesterol, DKD diabetic kidney disease