Effect of sitagliptin on the echocardiographic parameters of left ventricular diastolic function in patients with type 2 diabetes: a subgroup analysis of the PROLOGUE study

Yamada, Hirotsugu; Tanaka, Atsushi; Kusunose, Kenya; Amano, Rie; Matsuhisa, Munehide; Daida, Hiroyuki; Ito, Masaaki; Tsutsui, Hiroyuki; Nanasato, Mamoru; Kamiya, Haruo; Bando, Yasuko K.; Odawara, Masato; Yoshida, Hisako; Murohara, Toyoaki; Sata, Masataka; Node, Koichi

doi:10.1186/s12933-017-0546-2

Cardiovascular Diabetology

Table 2 Comparisons of echocardiographic parameters at baseline, 24 months and baseline-adjusted changes after 24 months of glycemic control

From: Effect of sitagliptin on the echocardiographic parameters of left ventricular diastolic function in patients with type 2 diabetes: a subgroup analysis of the PROLOGUE study

Variables	Baseline			24 months			Least square means of baseline-adjusted changes
Variables	Sitagliptin (n = 55)	Conventional (n = 60)	p value	Sitagliptin (n = 55)	Conventional (n = 60)	p value	Sitagliptin (n = 55)	Conventional (n = 60)	p value
TMF-E, cm/s	74.2 ± 32.6	69.3 ± 31.0	0.417	73.1 ± 33.4	73.6 ± 34.3	0.939	−0.85 ± 2.37	4.04 ± 2.27	0.139
e′, cm/s	6.35 ± 1.72	7.03 ± 2.13	0.065	6.60 ± 2.19	6.76 ± 2.11	0.684	0.13 ± 0.23	−0.16 ± 0.22	0.370
E/e′	12.17 ± 5.20	10.34 ± 4.18	0.040	12.19 ± 6.93	12.06 ± 7.06	0.922	−0.18 ± 0.55	1.91 ± 0.53	0.008
TMF-A, cm/s	80.1 ± 20.3 (n = 48)	83.4 ± 21.3 (n = 54)	0.424	82.4 ± 19.3 (n = 48)	88.2 ± 22.9 (n = 55)	0.168	3.06 ± 2.10 (n = 47)	5.73 ± 1.96 (n = 54)	0.354
E/A	0.91 ± 0.52(n = 48)	0.79 ± 0.24 (n = 54)	0.125	0.86 ± 0.35 (n = 48)	0.81 ± 0.31 (n = 54)	0.418	−0.03 ± 0.04 (n = 48)	−0.04 ± 0.04 (n = 54)	0.825
Deceleration time, msec	233.5 ± 65.8 (n = 50)	237.6 ± 67.7 (n = 55)	0.751	238.1 ± 78.1 (n = 52)	240.6 ± 64.6 (n = 58)	0.859	9.53 ± 9.06 (n = 49)	5.38 ± 8.63 (n = 54)	0.741
LV end-diastolic dimension, mm	48.5 ± 5.6	48.6 ± 5.9	0.912	47.5 ± 5.7	47.7 ± 5.3	0.836	−1.04 ± 0.51	−0.91 ± 0.48	0.855
LV end-systolic dimension, mm	31.7 ± 6.1	32.6 ± 7.2	0.462	31.5 ± 7.1	31.6 ± 6.9	0.935	−0.30 ± 0.60	−0.94 ± 0.58	0.447
Fractional shortening, %	35.1 ± 6.7	33.6 ± 7.9	0.279	33.9 ± 13.3	34.4 ± 8.5	0.787	−1.05 ± 1.31	0.64 ± 1.25	0.355
LV ejection fraction, %	63.6 ± 9.6	60.8 ± 10.8	0.153	62.5 ± 9.3	61.9 ± 9.8	0.721	−0.63 ± 0.85 (n = 54)	0.67 ± 0.81	0.273
LV mass, g	173.0 ± 66.6	160.2 ± 56.3	0.266	159.9 ± 49.1	159.2 ± 52.9	0.940	−10.29 ± 4.94	−3.50 ± 4.73	0.324
LV mass index, g/m²	101.6 ± 35.0	96.2 ± 30.6	0.383	94.8 ± 26.3	95.6 ± 28.3	0.881	−5.50 ± 2.81	−1.80 ± 2.68	0.343
Relative wall thickness	0.40 ± 0.09	0.38 ± 0.08	0.230	0.41 ± 0.08	0.39 ± 0.08	0.400	0.01 ± 0.01	0.00 ± 0.01	0.886
LA dimension, mm	40.8 ± 6.9 (n = 54)	40.0 ± 7.6 (n = 58)	0.572	39.7 ± 6.9	40.3 ± 6.9 (n = 59)	0.652	−0.87 ± 0.55 (n = 54)	0.25 ± 0.54 (n = 58)	0.151

Data for categorical variables are given as number (%); data for continuous variables given as mean ± standard deviation. In the right column, values are shown as baseline-adjusted least square mean ± standard error
TMF transmitral flow velocity, E early diastolic velocity, e′ early diastolic mitral annular velocity, LV left ventricular, LA left atrial

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