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Table 2 Comparisons of echocardiographic parameters at baseline, 24 months and baseline-adjusted changes after 24 months of glycemic control

From: Effect of sitagliptin on the echocardiographic parameters of left ventricular diastolic function in patients with type 2 diabetes: a subgroup analysis of the PROLOGUE study

Variables Baseline 24 months Least square means of baseline-adjusted changes
Sitagliptin (n = 55) Conventional (n = 60) p value Sitagliptin (n = 55) Conventional (n = 60) p value Sitagliptin (n = 55) Conventional (n = 60) p value
TMF-E, cm/s 74.2 ± 32.6 69.3 ± 31.0 0.417 73.1 ± 33.4 73.6 ± 34.3 0.939 −0.85 ± 2.37 4.04 ± 2.27 0.139
e′, cm/s 6.35 ± 1.72 7.03 ± 2.13 0.065 6.60 ± 2.19 6.76 ± 2.11 0.684 0.13 ± 0.23 −0.16 ± 0.22 0.370
E/e′ 12.17 ± 5.20 10.34 ± 4.18 0.040 12.19 ± 6.93 12.06 ± 7.06 0.922 −0.18 ± 0.55 1.91 ± 0.53 0.008
TMF-A, cm/s 80.1 ± 20.3 (n = 48) 83.4 ± 21.3 (n = 54) 0.424 82.4 ± 19.3 (n = 48) 88.2 ± 22.9 (n = 55) 0.168 3.06 ± 2.10 (n = 47) 5.73 ± 1.96 (n = 54) 0.354
E/A 0.91 ± 0.52(n = 48) 0.79 ± 0.24 (n = 54) 0.125 0.86 ± 0.35 (n = 48) 0.81 ± 0.31 (n = 54) 0.418 −0.03 ± 0.04 (n = 48) −0.04 ± 0.04 (n = 54) 0.825
Deceleration time, msec 233.5 ± 65.8 (n = 50) 237.6 ± 67.7 (n = 55) 0.751 238.1 ± 78.1 (n = 52) 240.6 ± 64.6 (n = 58) 0.859 9.53 ± 9.06 (n = 49) 5.38 ± 8.63 (n = 54) 0.741
LV end-diastolic dimension, mm 48.5 ± 5.6 48.6 ± 5.9 0.912 47.5 ± 5.7 47.7 ± 5.3 0.836 −1.04 ± 0.51 −0.91 ± 0.48 0.855
LV end-systolic dimension, mm 31.7 ± 6.1 32.6 ± 7.2 0.462 31.5 ± 7.1 31.6 ± 6.9 0.935 −0.30 ± 0.60 −0.94 ± 0.58 0.447
Fractional shortening,  % 35.1 ± 6.7 33.6 ± 7.9 0.279 33.9 ± 13.3 34.4 ± 8.5 0.787 −1.05 ± 1.31 0.64 ± 1.25 0.355
LV ejection fraction,  % 63.6 ± 9.6 60.8 ± 10.8 0.153 62.5 ± 9.3 61.9 ± 9.8 0.721 −0.63 ± 0.85 (n = 54) 0.67 ± 0.81 0.273
LV mass, g 173.0 ± 66.6 160.2 ± 56.3 0.266 159.9 ± 49.1 159.2 ± 52.9 0.940 −10.29 ± 4.94 −3.50 ± 4.73 0.324
LV mass index, g/m2 101.6 ± 35.0 96.2 ± 30.6 0.383 94.8 ± 26.3 95.6 ± 28.3 0.881 −5.50 ± 2.81 −1.80 ± 2.68 0.343
Relative wall thickness 0.40 ± 0.09 0.38 ± 0.08 0.230 0.41 ± 0.08 0.39 ± 0.08 0.400 0.01 ± 0.01 0.00 ± 0.01 0.886
LA dimension, mm 40.8 ± 6.9 (n = 54) 40.0 ± 7.6 (n = 58) 0.572 39.7 ± 6.9 40.3 ± 6.9 (n = 59) 0.652 −0.87 ± 0.55 (n = 54) 0.25 ± 0.54 (n = 58) 0.151
  1. Data for categorical variables are given as number (%); data for continuous variables given as mean ± standard deviation. In the right column, values are shown as baseline-adjusted least square mean ± standard error
  2. TMF transmitral flow velocity, E early diastolic velocity, e′ early diastolic mitral annular velocity, LV left ventricular, LA left atrial