|
Age, year
|
69 ± 8
|
69 ± 9
|
0.973
| | | | | | |
|
Gender (male/female)
|
38/17
|
39/21
|
0.641
| | | | | | |
|
Body mass index, kg/m2
|
25.9 ± 3.3
|
24.8 ± 3.9
|
0.098
|
25.5 ± 3.4
|
24.6 ± 3.8
|
0.203
|
−0.10 ± 0.16
|
−0.13 ± 0.15
|
0.368
|
|
Systolic BP, mmHg
|
132 ± 17
|
129 ± 19
|
0.287
|
133 ± 16
|
130 ± 20
|
0.377
|
1.70 ± 2.20 (n = 54)
|
0.34 ± 2.09
|
0.656
|
|
Diastolic BP, mmHg
|
74 ± 11
|
71 ± 12
|
0.090
|
75 ± 13 (n = 54)
|
71 ± 11
|
0.076
|
1.76 ± 1.47 (n = 54)
|
−0.54 ± 1.40
|
0.263
|
|
Heart rate, beats/min
|
70 ± 12
|
67 ± 12
|
0.196
|
71 ± 16
|
67 ± 10
|
0.129
|
3.37 ± 1.49
|
−2.14 ± 1.43
|
0.009
|
|
Total cholesterol, mmol/L
|
4.4 ± 0.8
|
4.6 ± 0.9
|
0.43
|
4.4 ± 0.8 (n = 54)
|
4.4 ± 1.0
|
0.690
|
−0.08 ± 0.09 (n = 54)
|
−0.10 ± 0.08
|
0.899
|
|
HDL cholesterol, mmol/L
|
1.3 ± 0.3 (n = 55)
|
1.4 ± 0.4 (n = 58)
|
0.617
|
1.3 ± 0.3 (n = 54)
|
1.4 ± 0.4
|
0.412
|
−0.03 ± 0.03 (n = 54)
|
0.00 ± 0.03 (n = 58)
|
0.362
|
|
Triglycerides, mmol/L
|
3.1 [2.2–4.5] (n = 54)
|
3.1 [2.3–4.2]
|
0.536
|
2.9 [2.2–5.0] (n = 54)
|
2.9 [2.1–3.9]
|
0.151
|
0.06 ± 0.06 (n = 53)
|
−0.08 ± 0.05
|
0.078
|
|
Creatinine, μmol/L
|
71.6 [61.9–86.6]
|
68.1 [59.2–89.3]
|
0.496
|
75.1 [62.8–87.5] (n = 54)
|
69.0 [61.0–98.1]
|
0.740
|
2.65 ± 1.77 (n = 54)
|
4.42 ± 1.77
|
0.345
|
|
eGFR, mL/min/1.73 m2
|
66.6 ± 15.9
|
67.3 ± 18.4
|
0.834
|
65.1 ± 14.1 (n = 54)
|
67.1 ± 19.7
|
0.757
|
−1.96 ± 1.10 (n = 54)
|
–3.18 ± 1.04
|
0.419
|
|
Fasting plasma glucose, mmol/L
|
7.5 ± 1.8 (n = 53)
|
7.1 ± 1.4
|
0.135
|
7.0 ± 1.6 (n = 54)
|
6.7 ± 1.7 (n = 58)
|
0.248
|
−0.41 ± 0.20 (n = 52)
|
−0.49 ± 0.19 (n = 58)
|
0.780
|
|
HbA1c, %
|
7.0 ± 0.6
|
6.9 ± 0.5
|
0.737
|
6.5 ± 0.6 (n = 54)
|
6.6 ± 0.7
|
0.412
|
−0.47 ± 0.08 (n = 52)
|
−0.34 ± 0.07 (n = 57)
|
0.211
|
|
1,5AG, µg/mL
|
13.9 [8.3–20.3] (n = 52)
|
15.6 [10.7–22.8] (n = 58)
|
0.086
|
16.4 [8.7–22.6]
|
15.1 [9.6–25.0] (n = 59)
|
0.747
|
2.55 ± 0.82 (n = 52)
|
0.95 ± 0.79 (n = 57)
|
0.165
|
|
NT-proBNP, pg/mL
|
111.5 [42.1–240.8] (n = 52)
|
99.6 [52.1–234.9] (n = 58)
|
0.848
|
114.5 [51.8–261.9]
|
114.1 [60.2–323.8] (n = 59)
|
0.673
|
0.09 ± 0.08 (n = 52)
|
0.16 ± 0.08 (n = 57)
|
0.535
|
|
High-sensitive CRP, ng/mL
|
540 [279–1100] (n = 52)
|
576 [236–1618] (n = 58)
|
0.952
|
478 [232–1150] (n = 55)
|
478 [199–1590] (n = 59)
|
0.984
|
−0.06 ± 0.16 (n = 52)
|
−0.06 ± 0.15 (n = 57)
|
0.983
|
|
Current smoker, n (%)
|
8 (17.4) (n = 46)
|
13 (28.3) (n = 46)
|
0.321
| | | | | | |
|
Hypertension, n (%)
|
45 (81.8)
|
46 (76.7)
|
0.497
| | | | | | |
|
Dyslipidemia, n (%)
|
42 (76.4)
|
42 (70.0)
|
0.530
| | | | | | |
|
Cerebrovascular disease, n (%)
|
8 (14.6)
|
4 (6.7)
|
0.226
| | | | | | |
|
Cardiovascular disease, n (%)
|
38 (69.1)
|
41 (68.3)
|
0.930
| | | | | | |
|
Chronic heart failure, n (%)
|
3 (5.5)
|
7 (11.7)
|
0.326
| | | | | | |
|
Medications
|
|
ACE inhibitor or ARB
|
37 (67.3)
|
42 (70.0)
|
0.753
|
39 (70.9)
|
41 (68.3)
|
0.764
| | | |
|
β-blocker
|
12 (21.8)
|
11 (18.3)
|
0.641
|
13 (23.6)
|
12 (20.0)
|
0.637
| | | |
|
Diuretic
|
17 (30.9)
|
12 (20.0)
|
0.178
|
16 (29.1)
|
15 (25.0)
|
0.621
| | | |
|
Statin
|
42 (76.4)
|
40 (66.7)
|
0.251
|
39 (70.9)
|
39 (65.0)
|
0.498
| | | |
|
α-Glucosidase inhibitor, n (%)
|
23 (41.8)
|
30 (50.0)
|
0.455
|
18 (32.7)
|
38 (63.3)
|
0.001
| | | |
|
Glinide, n (%)
|
4 (7.3)
|
4 (6.7)
|
0.899
|
2 (3.6)
|
5 (8.3)
|
0.293
| | | |
|
Biguanide, n (%)
|
9 (16.4)
|
10 (16.7)
|
0.965
|
12 (21.8)
|
16 (26.7)
|
0.545
| | | |
|
Sulfonylurea, n (%)
|
9 (16.4)
|
12 (20.0)
|
0.638
|
4 (7.3)
|
18 (30.0)
|
0.002
| | | |
|
Thiazolidinedione, n (%)
|
11 (20.0)
|
18 (30.0)
|
0.283
|
9 (16.4)
|
23 (38.3)
|
0.009
| | | |
