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Fig. 5 | Cardiovascular Diabetology

Fig. 5

From: Dipeptidyl peptidase-4 (DPP-4) inhibition with linagliptin reduces western diet-induced myocardial TRAF3IP2 expression, inflammation and fibrosis in female mice

Fig. 5

Linagliptin prevents WD-induced increases in TRAF3IP2 expression. a Western blot shows myocardial TRAF3IP2 expression and accompanying bar graphs b show quantitative analysis of protein and mRNA expression as fold change from baseline in the CD group. c Immunofluorescent localization of TRAF3IP2 in the myocardium. The left panels show co-localization of phalloidin (cardiomyocytes, green) and TRAF3IP2 (red). The right panels show colocalization of CD31 (endothelial cells,) and TRAF3IP2 (yellow). d Bar graphs show quantitative analysis of TRAF3IP2 immunofluorescence in the myocardium (top bar graph) and in the coronary endothelium (bottom bar graph) expressed relative to CD. *p < 0.05 vs CD and †p < 0.05 vs WD. N = 5–6/group

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