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Fig. 2 | Cardiovascular Diabetology

Fig. 2

From: Dipeptidyl peptidase-4 (DPP-4) inhibition with linagliptin reduces western diet-induced myocardial TRAF3IP2 expression, inflammation and fibrosis in female mice

Fig. 2

Linagliptin prevents WD-induced cardiac fibrosis. a WD induces profibrotic mineralocorticoid receptor (MR) protein expression and this effect is blunted by linagliptin. b Representative micrographs (4× with 40× inset) show interstitial fibrosis by picrosirius red (PSR) staining in the heart and semi-quantitative assessment of PSR staining. Scale bars 50 μm. c Bar graphs show quantitative analysis of RT-qPCR- generated mRNA results for Col Iα, Col IIIα1, CTGF and LOX expressed as fold change from baseline in the CD group. *p < 0.05 vs CD and †p < 0.05 vs WD. N = 5–8/group

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Cardiovascular Diabetology

ISSN: 1475-2840