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Table 2 Left ventricular function determined by cine MRI after 8 weeks of HFD and metformin or sulodexide treatment

From: Metformin and sulodexide restore cardiac microvascular perfusion capacity in diet-induced obese rats

 

Baseline

Adenosine

Control

N = 5

HFD

N = 8

Metformin

N = 8

Sulodexide

N = 7

Control

N = 5

HFD

N = 8

Metformin

N = 8

Sulodexide

N = 7

Heart rate (bpm)

384 ± 17

397 ± 10

428 ± 27

386 ± 7

327 ± 21†

333 ± 23†

361 ± 30†

317 ± 14†

EDV (µl)

316 ± 33

285 ± 29

294 ± 23

324 ± 48

348 ± 30

394 ± 25†

328 ± 39

400 ± 47†

ESV (µl)

83 ± 18

71 ± 7

72 ± 16

46 ± 11

55 ± 8

87 ± 14

45 ± 11#

61 ± 14†

SV (µl)

233 ± 42

214 ± 27

222 ± 32

278 ± 53

294 ± 27

306 ± 32†

282 ± 45

339 ± 55

EF (%)

72 ± 5

74 ± 2

74 ± 6

82 ± 6

84 ± 2

77 ± 4

84 ± 5†

83 ± 6

  1. Data are expressed as mean ± SEM
  2. HFD high fat diet, EDV end-diastolic volume, SV stroke volume, EF ejection fraction
  3. * p < 0.05 vs. control group, # p < 0.05 vs. HFD group, † p < 0.05 adenosine effect. No significant differences were found for the intervention groups HFD, metformin and sulodexide compared to the control group