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Table 2 Left ventricular function determined by cine MRI after 8 weeks of HFD and metformin or sulodexide treatment

From: Metformin and sulodexide restore cardiac microvascular perfusion capacity in diet-induced obese rats

  Baseline Adenosine
Control
N = 5
HFD
N = 8
Metformin
N = 8
Sulodexide
N = 7
Control
N = 5
HFD
N = 8
Metformin
N = 8
Sulodexide
N = 7
Heart rate (bpm) 384 ± 17 397 ± 10 428 ± 27 386 ± 7 327 ± 21 333 ± 23 361 ± 30 317 ± 14
EDV (µl) 316 ± 33 285 ± 29 294 ± 23 324 ± 48 348 ± 30 394 ± 25 328 ± 39 400 ± 47
ESV (µl) 83 ± 18 71 ± 7 72 ± 16 46 ± 11 55 ± 8 87 ± 14 45 ± 11# 61 ± 14
SV (µl) 233 ± 42 214 ± 27 222 ± 32 278 ± 53 294 ± 27 306 ± 32 282 ± 45 339 ± 55
EF (%) 72 ± 5 74 ± 2 74 ± 6 82 ± 6 84 ± 2 77 ± 4 84 ± 5 83 ± 6
  1. Data are expressed as mean ± SEM
  2. HFD high fat diet, EDV end-diastolic volume, SV stroke volume, EF ejection fraction
  3. * p < 0.05 vs. control group, # p < 0.05 vs. HFD group,  p < 0.05 adenosine effect. No significant differences were found for the intervention groups HFD, metformin and sulodexide compared to the control group