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Table 1 Morphometric data and plasma values of rats in absence or presence of metformin or sulodexide

From: Metformin and sulodexide restore cardiac microvascular perfusion capacity in diet-induced obese rats

  Control
N = 5
HFD
N = 8
Metformin
N = 8
Sulodexide
N = 7
Body composition
 Body weight (g) 389.6 ± 12.9 528.3 ± 11.6* 532.5 ± 16.2* 555.1 ± 188*
 Heart weight (g) 1.00 ± 0.09 1.29 ± 0.05* 1.39 ± 0.08* 1.33 ± 0.04*
 Heart weight/body weight (×1000) 2.55 ± 0.15 2.44 ± 0.09 2.61 ± 0.13 2.40 ± 0.06
 Perirenal fat (g) 3.44 ± 0.40 14.15 ± 1.57* 15.90 ± 1.52* 16.21 ± 1.27*
 Epididymal fat (g) 3.88 ± 0.41 10.19 ± 1.23* 10.85 ± 0.84* 13.00 ± 1.62*
Blood/plasma characteristics
 Haematocrit (%) 50.5 ± 0.5 50.5 ± 1.5 51.3 ± 0.5 48.3 ± 0.4
 Total cholesterol (mmol/l) 2.14 ± 0.22 2.86 ± 0.14* 2.58 ± 0.21 2.79 ± 0.05*
 Triglycerides (mmol/l) 0.76 ± 0.09 0.97 ± 0.18 0.71 ± 0.11 0.96 ± 0.21
 Fasted blood glucose (mmol/l)a 6.66 ± 0.37 7.48 ± 0.57 7.42 ± 0.50 7.00 ± 0.60
 Fasted insulin (ng/ml)a 0.16 ± 0.01 0.76 ± 0.13* 0.59 ± 0.10* 0.30 ± 0.06#
  1. Data are expressed as mean ± SEM
  2. HFD high fat diet
  3. * p < 0.05 vs. control group, # p < 0.05 vs. HFD group
  4. aSeparate series of experiments (control n = 9, HFD n = 9, metformin n = 9, sulodexide n = 6)