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Table 1 Morphometric data and plasma values of rats in absence or presence of metformin or sulodexide

From: Metformin and sulodexide restore cardiac microvascular perfusion capacity in diet-induced obese rats

 

Control

N = 5

HFD

N = 8

Metformin

N = 8

Sulodexide

N = 7

Body composition

 Body weight (g)

389.6 ± 12.9

528.3 ± 11.6*

532.5 ± 16.2*

555.1 ± 188*

 Heart weight (g)

1.00 ± 0.09

1.29 ± 0.05*

1.39 ± 0.08*

1.33 ± 0.04*

 Heart weight/body weight (×1000)

2.55 ± 0.15

2.44 ± 0.09

2.61 ± 0.13

2.40 ± 0.06

 Perirenal fat (g)

3.44 ± 0.40

14.15 ± 1.57*

15.90 ± 1.52*

16.21 ± 1.27*

 Epididymal fat (g)

3.88 ± 0.41

10.19 ± 1.23*

10.85 ± 0.84*

13.00 ± 1.62*

Blood/plasma characteristics

 Haematocrit (%)

50.5 ± 0.5

50.5 ± 1.5

51.3 ± 0.5

48.3 ± 0.4

 Total cholesterol (mmol/l)

2.14 ± 0.22

2.86 ± 0.14*

2.58 ± 0.21

2.79 ± 0.05*

 Triglycerides (mmol/l)

0.76 ± 0.09

0.97 ± 0.18

0.71 ± 0.11

0.96 ± 0.21

 Fasted blood glucose (mmol/l)a

6.66 ± 0.37

7.48 ± 0.57

7.42 ± 0.50

7.00 ± 0.60

 Fasted insulin (ng/ml)a

0.16 ± 0.01

0.76 ± 0.13*

0.59 ± 0.10*

0.30 ± 0.06#

  1. Data are expressed as mean ± SEM
  2. HFD high fat diet
  3. * p < 0.05 vs. control group, # p < 0.05 vs. HFD group
  4. aSeparate series of experiments (control n = 9, HFD n = 9, metformin n = 9, sulodexide n = 6)