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Table 3 Cox regression analysis on long-term outcome (mortality and amputation)

From: Impact of diabetes on outcome in critical limb ischemia with tissue loss: a large-scaled routine data analysis

 

Rutherford grade 5

Rutherford grade 6

Mortality

Amputation

Mortality

Amputation

HR (95% CI)

P

HR (95% CI)

P

HR (95% CI)

P

HR (95% CI)

P

Age

1.05 (1.04–1.05)

<0.001

0.99 (0.99–1.00)

0.010

1.05 (1.05–1.06)

<0.001

1.00 (1.00–1.00)

0.951

Male gender

1.13 (1.04–1.23)

0.003

1.48 (1.34–1.63)

<0.001

1.14 (1.07–1.22)

<0.001

1.27 (1.20–1.35)

<0.001

Hypertension

0.80 (0.74–0.86)

<0.001

0.91 (0.82–1.01)

0.066

0.82 (0.77–0.88)

<0.001

0.93 (0.87–0.99)

0.017

Obesity

0.68 (0.57–0.82)

<0.001

0.79 (0.66–0.94)

0.007

0.81 (0.70–0.93)

0.002

0.96 (0.87–1.07)

0.502

Dyslipidemia

0.75 (0.68–0.82)

<0.001

0.96 (0.86–1.07)

0.442

0.76 (0.70–0.83)

<0.001

0.85 (0.79–0.92)

<0.001

Smoking

0.99 (0.81–1.20)

0.896

0.91 (0.75–1.11)

0.372

0.98 (0.84–1.14)

0.804

0.81 (0.72–0.92)

0.001

Diabetes

0.95 (0.88–1.03)

0.222

1.51 (1.38–1.67)

<0.001

0.92 (0.86–0.98)

0.009

1.33 (1.25–1.41)

<0.001

CAD

1.20 (1.10–1.31)

<0.001

1.04 (0.93–1.16)

0.479

1.25 (1.17–1.34)

<0.001

0.98 (0.91–1.05)

0.514

CHF

1.63 (1.49–1.79)

<0.001

0.94 (0.82–1.08)

0.410

1.50 (1.39–1.61)

<0.001

1.10 (1.02–1.19)

0.012

CKD

1.55 (1.43–1.68)

<0.001

1.33 (1.20–1.47)

<0.001

1.38 (1.30–1.47)

<0.001

0.98 (0.92–1.05)

0.572

Malignancies

1.73 (1.38–2.16)

<0.001

0.97 (0.68–1.37)

0.855

1.93 (1.66–2.24)

<0.001

0.86 (0.72–1.03)

0.106

  1. Cox regression analysis for the end-points mortality and amputation during the 4-year follow-up period in patients at Rutherford grade 5 and Rutherford grade 6. In the proportional hazards model, effect of included variables are presented as Hazard Ratio and corresponding confidence intervals, p values <0.05 are considered significant
  2. Italic values are statistically significant
  3. HR Hazard Ratio; CI confidence interval; CAD coronary artery disease; CHF chronic heart failure; CKD chronic kidney disease