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Table 3 Cox regression analysis on long-term outcome (mortality and amputation)

From: Impact of diabetes on outcome in critical limb ischemia with tissue loss: a large-scaled routine data analysis

  Rutherford grade 5 Rutherford grade 6
Mortality Amputation Mortality Amputation
HR (95% CI) P HR (95% CI) P HR (95% CI) P HR (95% CI) P
Age 1.05 (1.04–1.05) <0.001 0.99 (0.99–1.00) 0.010 1.05 (1.05–1.06) <0.001 1.00 (1.00–1.00) 0.951
Male gender 1.13 (1.04–1.23) 0.003 1.48 (1.34–1.63) <0.001 1.14 (1.07–1.22) <0.001 1.27 (1.20–1.35) <0.001
Hypertension 0.80 (0.74–0.86) <0.001 0.91 (0.82–1.01) 0.066 0.82 (0.77–0.88) <0.001 0.93 (0.87–0.99) 0.017
Obesity 0.68 (0.57–0.82) <0.001 0.79 (0.66–0.94) 0.007 0.81 (0.70–0.93) 0.002 0.96 (0.87–1.07) 0.502
Dyslipidemia 0.75 (0.68–0.82) <0.001 0.96 (0.86–1.07) 0.442 0.76 (0.70–0.83) <0.001 0.85 (0.79–0.92) <0.001
Smoking 0.99 (0.81–1.20) 0.896 0.91 (0.75–1.11) 0.372 0.98 (0.84–1.14) 0.804 0.81 (0.72–0.92) 0.001
Diabetes 0.95 (0.88–1.03) 0.222 1.51 (1.38–1.67) <0.001 0.92 (0.86–0.98) 0.009 1.33 (1.25–1.41) <0.001
CAD 1.20 (1.10–1.31) <0.001 1.04 (0.93–1.16) 0.479 1.25 (1.17–1.34) <0.001 0.98 (0.91–1.05) 0.514
CHF 1.63 (1.49–1.79) <0.001 0.94 (0.82–1.08) 0.410 1.50 (1.39–1.61) <0.001 1.10 (1.02–1.19) 0.012
CKD 1.55 (1.43–1.68) <0.001 1.33 (1.20–1.47) <0.001 1.38 (1.30–1.47) <0.001 0.98 (0.92–1.05) 0.572
Malignancies 1.73 (1.38–2.16) <0.001 0.97 (0.68–1.37) 0.855 1.93 (1.66–2.24) <0.001 0.86 (0.72–1.03) 0.106
  1. Cox regression analysis for the end-points mortality and amputation during the 4-year follow-up period in patients at Rutherford grade 5 and Rutherford grade 6. In the proportional hazards model, effect of included variables are presented as Hazard Ratio and corresponding confidence intervals, p values <0.05 are considered significant
  2. Italic values are statistically significant
  3. HR Hazard Ratio; CI confidence interval; CAD coronary artery disease; CHF chronic heart failure; CKD chronic kidney disease