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Table 3 Biochemical variables according to obstructive sleep apnea severity

From: Association between obstructive sleep apnea severity and endothelial dysfunction in patients with type 2 diabetes

  AHI < 15 15 ≤ AHI < 30 AHI > 30 p value p value*
HbA1C,  % 8.0 (1.7) 7.3 (1.4) 7.4 (1.2) 0.05
Glucose, mmol/l 8.4 (2.2) 7.8 (2.3) 7.9 (1.9) 0.34
Insulin, mU/l 15.3 (11.2) 22.2 (25.0) 15.0 (10.4) 0.11
HOMA-IR 5.6 (4.9) 8.1 (9.5) 5.3 (3.9) 0.13
TC, mmol/l 4.6 (1.0) 4.6 (1.3) 4.6 (0.8) 0.99
HDLc, mmol/l 1.1 (0.2) 1.0 (0.2) 1.0 (0.2) 0.18
LDLc, mmol/l 2.7 (1.0) 2.9 (1.3) 2.7 (0.5) 0.88
TG, mmol/l 1.7 (0.9) 1.6 (0.6) 2.3 (1.3) 0.18
Adiponectin, µg/ml 14.7 (7.1) 9.2 (6.3) 9.3 (6.4) 0.0004 0.0009
Leptin, ng/ml 30.9 (20.5) 38.8 (34.2) 33.5 (25.9) 0.54
Leptin/adiponectin 3.5 (3.8) 5.4 (5.1) 5.5 (6.5) 0.19
8-isoprostane, pg/ml 401.7 (142.8) 235.7 (157.4) 304.1 (195.1) 0.01 0.09
hs-CRP, µg/ml 45.1 (60.7) 30.7 (30.7) 40.3 (35.8) 0.45
sP-sel, ng/ml 38.4 (17.9) 54.9 (36.9) 50.8 (25.6) 0.03 0.03
Circulating MPs (n = 43)
 CD62E+ MPs/ml 70.4 (45.4) 113.2 (116.5) 76.0 (66.6) 0.3882
 CD62P+ MPs/250 × 103platelets/ml 37.3 (22.7) 54.8 (41.2) 64.1 (37.4) 0.0838
  1. Data are expressed as mean (standard deviation)
  2. HbA 1C glycated hemoglobin, HOMA-IR homeostasis model assessment of insulin resistance, TC total cholesterol, HDLc high-density lipoprotein cholesterol, LDLc low-density lipoprotein cholesterol, TG triglycerides, hs-CRP high-sensitivity C-reactive protein, sP-sel soluble P-selectin, MPs microparticles
  3. * p values were adjusted for age, gender, body mass index, insulin and injectable GLP-1 analog use