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Table 3 Biochemical variables according to obstructive sleep apnea severity

From: Association between obstructive sleep apnea severity and endothelial dysfunction in patients with type 2 diabetes

 

AHI < 15

15 ≤ AHI < 30

AHI > 30

p value

p value*

HbA1C,  %

8.0 (1.7)

7.3 (1.4)

7.4 (1.2)

0.05

Glucose, mmol/l

8.4 (2.2)

7.8 (2.3)

7.9 (1.9)

0.34

Insulin, mU/l

15.3 (11.2)

22.2 (25.0)

15.0 (10.4)

0.11

HOMA-IR

5.6 (4.9)

8.1 (9.5)

5.3 (3.9)

0.13

TC, mmol/l

4.6 (1.0)

4.6 (1.3)

4.6 (0.8)

0.99

HDLc, mmol/l

1.1 (0.2)

1.0 (0.2)

1.0 (0.2)

0.18

LDLc, mmol/l

2.7 (1.0)

2.9 (1.3)

2.7 (0.5)

0.88

TG, mmol/l

1.7 (0.9)

1.6 (0.6)

2.3 (1.3)

0.18

Adiponectin, µg/ml

14.7 (7.1)

9.2 (6.3)

9.3 (6.4)

0.0004

0.0009

Leptin, ng/ml

30.9 (20.5)

38.8 (34.2)

33.5 (25.9)

0.54

Leptin/adiponectin

3.5 (3.8)

5.4 (5.1)

5.5 (6.5)

0.19

8-isoprostane, pg/ml

401.7 (142.8)

235.7 (157.4)

304.1 (195.1)

0.01

0.09

hs-CRP, µg/ml

45.1 (60.7)

30.7 (30.7)

40.3 (35.8)

0.45

sP-sel, ng/ml

38.4 (17.9)

54.9 (36.9)

50.8 (25.6)

0.03

0.03

Circulating MPs (n = 43)

 CD62E+ MPs/ml

70.4 (45.4)

113.2 (116.5)

76.0 (66.6)

0.3882

 CD62P+ MPs/250 × 103platelets/ml

37.3 (22.7)

54.8 (41.2)

64.1 (37.4)

0.0838

  1. Data are expressed as mean (standard deviation)
  2. HbA 1C glycated hemoglobin, HOMA-IR homeostasis model assessment of insulin resistance, TC total cholesterol, HDLc high-density lipoprotein cholesterol, LDLc low-density lipoprotein cholesterol, TG triglycerides, hs-CRP high-sensitivity C-reactive protein, sP-sel soluble P-selectin, MPs microparticles
  3. * p values were adjusted for age, gender, body mass index, insulin and injectable GLP-1 analog use