Subclinical left ventricular diastolic dysfunction and incident type 2 diabetes risk: the Korean Genome and Epidemiology Study

Table 4 Echocardiographic predictors of incident type 2 diabetes in a subgroup stratified according to baseline glucose metabolism (NGM vs. prediabetes), adjusting for age, sex, BMI ≥23 kg/m², fasting plasma glucose, 2-h plasma glucose, hypertension, statin therapy, family history of diabetes, smoking status, alcohol intake, HOMA-IR, total cholesterol, TG/HDL ratio, and hsCRP: multivariate logistic regression analyses

Variables	NGM (n = 788)			Prediabetes (n = 1029)
Variables	OR (95% CI)	P value	P value^a	OR (95% CI)	P value	P value^a
LA volume index (mL/m²)	1.037 (0.982–1.095)	0.190	1.000	1.021 (0.993–1.048)	0.140	1.000
LV mass index (g/m²)	0.999 (0.973–1.026)	0.948	1.000	1.014 (1.004–1.025)	0.009	0.126
LV hypertrophy (yes vs. no)	0.848 (0.268–2.683)	0.779	1.000	1.315 (0.833–2.074)	0.240	1.000
TDI Sm velocity (cm/s)	0.892 (0.633–1.257)	0.513	1.000	0.872 (0.764–0.995)	0.041	0.574
TDI Em velocity (cm/s)	0.958 (0.725–1.267)	0.765	1.000	0.864 (0.770–0.968)	0.012	0.168
E/Em ratio	1.078 (0.900–1.292)	0.416	1.000	1.064 (1.000–1.134)	0.051	0.714
LV diastolic dysfunction (yes vs. no)	1.000 (0.389–2.575)	0.999	1.000	1.906 (1.335–2.721)	<0.001	0.005

BMI body mass index, CI confidence interval, HDL high-density lipoprotein, HOMA-IR homeostasis model assessment-insulin resistance, hsCRP high sensitivity C-reactive protein, LV left ventricle, NGM normal glucose metabolism, OR odds ratio, TDI tissue Doppler imaging, TG triglycerides
^aCorrected P values using Bonferroni method for multiple comparisons

ISSN: 1475-2840