Table 2 Current and potential future strategies to enhance fibrinolysis and reduce thrombosis risk in diabetes

Improve glycaemic control

Agents which control blood glucose while avoiding hypoglycaemia

Decrease levels of active TAFI

Inhibit activation of TAFI [147–151]

Direct TAFIa inhibitors [147–151]

Decrease levels of active PAI-1

Inhibition of PAI-1 synthesis [114]

Direct PAI-1 inhibition [114, 148, 156–165]

Decrease incorporation of plasmin inhibitor (PI) into the clot

Antibodies [167–170]

PI mutants [173, 174]

N- and C-terminal peptides of PI [178–180]

Inhibition of antiplasmin cleaving enzyme [185]

Decrease incorporation of C3 into the clot

Targeted disruption of the fibrinogen-C3 interaction [188]