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Table 2 Risk of incident type 2 diabetes mellitus (T2DM) by quartiles of TyG and TyG-D

From: Cumulative increased risk of incident type 2 diabetes mellitus with increasing triglyceride glucose index in normal-weight people: The Rural Chinese Cohort Study

  Quartile 1 Quartile 2 Quartile 3 Quartile 4 P trend
TyG
 Range <8.16 8.16 to 8.47 8.48 to 8.81 ≥8.82  
 No. of cases 18 35 52 88  
 No. of person-years 8740.50 8526.83 8529.25 8399.50  
 Incidence ratea 2.06 4.10 6.10 10.48 <0.001
 Unadjusted model 1 (ref) 2.36 (1.33–4.16) 3.58 (2.09–6.12) 6.30 (3.78–10.50) <0.001
 Multivariable adjusted model 1b 1 (ref) 2.38 (1.17–4.85) 3.71 (1.89–7.29) 5.54 (2.87–10.71) <0.001
 Multivariable adjusted model 2c 1 (ref) 2.49 (1.22–5.08) 3.89 (1.98–7.65) 5.69 (2.94–11.01) <0.001
 Multivariable adjusted model 3d 1 (ref) 2.48 (1.20–5.11) 3.77 (1.83–7.79) 5.30 (2.21–12.71) <0.001
TyG-D
 Range <−0.27 −0.27 to 0 0.01 to 0.31 ≥0.32  
 No. of cases 41 39 30 83  
 No. of person-years 8520.00 9747.08 7373.00 8556.00  
 Incidence ratea 4.81 4.00 4.07 9.70 <0.001
 Unadjusted model 1 (ref) 0.95 (0.58–1.55) 1.15 (0.68–1.93) 2.19 (1.41–3.39) <0.001
 Multivariable adjusted model 1b 1 (ref) 0.92 (0.52–1.63) 1.09 (0.59–2.03) 2.51 (1.50–4.19) <0.001
 Multivariable adjusted model 2c 1 (ref) 0.92 (0.52–1.64) 1.10 (0.59–2.05) 2.52 (1.51–4.22) <0.001
 Multivariable adjusted model 3d 1 (ref) 1.14 (0.63–2.09) 1.54 (0.80–2.99) 3.91 (2.22–6.87) <0.001
  1. Data are hazard ratios (HRs) and 95% confidence intervals (95% CIs)
  2. TyG triglyceride glucose index, TyG-D difference in TyG value at the end of follow-up minus that at baseline
  3. aPer 1000 person-years
  4. bAdjusted for gender, age, family history of diabetes and WC
  5. cAdjusted for variables in b as well as education level, marital status, smoking, alcohol consumption and physical activity
  6. dAdjusted for variables in c as well as SBP, DBP and TC, HDL-C and LDL-C levels