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Table 1 Impact of the Nrf2 activator dh404 on metabolic parameters in WT and Akita mice

From: The nuclear factor (erythroid-derived 2)-like 2 (Nrf2) activator dh404 protects against diabetes-induced endothelial dysfunction

 

WT + vehicle

WT + dh404

Akita + vehicle

Akita + dh404

Body weight (g)

32.3 ± 1.1

30.9 ± 1.1

21.5 ± 0.6****

21.9 ± 0.6****

Blood glucose (mmol/L)

12.9 ± 1.0

11.6 ± 1.2

40.5 ± 3.7****

39.0 ± 4.1****

HbA1c (%)

4.5 ± 0.1

4.9 ± 0.1

13.0 ± 0.3****

12.0 ± 0.7****

Cholesterol (mmol/L)

1.8 ± 0.1

1.9 ± 0.1

1.7 ± 0.1

1.8 ± 0.2

Triglycerides (mmol/L)

0.6 ± 0.1

0.2 ± 0.1

0.9 ± 0.5

1.0 ± 0.3

HDL (mmol/L)

1.4 ± 0.1

1.5 ± 0.1

1.0 ± 0.1

1.1 ± 0.1

LDL (mmol/L)

0.2 ± 0.1

0.4 ± 0.1

0.5 ± 0.1

0.5 ± 0.1

LH ratio

0.2 ± 0.1

0.3 ± 0.1

0.7 ± 0.3

0.6 ± 0.2

  1. Body weight, blood glucose, Hb1Ac, cholesterol, tryglycerides, HDL, LDL, and LH ratio were measured at 26 weeks of age. Data are presented as ±SEM. (**** P < 0.0001 vs. WT + vehicle; n = 7/group)