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Table 1 Impact of the Nrf2 activator dh404 on metabolic parameters in WT and Akita mice

From: The nuclear factor (erythroid-derived 2)-like 2 (Nrf2) activator dh404 protects against diabetes-induced endothelial dysfunction

  WT + vehicle WT + dh404 Akita + vehicle Akita + dh404
Body weight (g) 32.3 ± 1.1 30.9 ± 1.1 21.5 ± 0.6**** 21.9 ± 0.6****
Blood glucose (mmol/L) 12.9 ± 1.0 11.6 ± 1.2 40.5 ± 3.7**** 39.0 ± 4.1****
HbA1c (%) 4.5 ± 0.1 4.9 ± 0.1 13.0 ± 0.3**** 12.0 ± 0.7****
Cholesterol (mmol/L) 1.8 ± 0.1 1.9 ± 0.1 1.7 ± 0.1 1.8 ± 0.2
Triglycerides (mmol/L) 0.6 ± 0.1 0.2 ± 0.1 0.9 ± 0.5 1.0 ± 0.3
HDL (mmol/L) 1.4 ± 0.1 1.5 ± 0.1 1.0 ± 0.1 1.1 ± 0.1
LDL (mmol/L) 0.2 ± 0.1 0.4 ± 0.1 0.5 ± 0.1 0.5 ± 0.1
LH ratio 0.2 ± 0.1 0.3 ± 0.1 0.7 ± 0.3 0.6 ± 0.2
  1. Body weight, blood glucose, Hb1Ac, cholesterol, tryglycerides, HDL, LDL, and LH ratio were measured at 26 weeks of age. Data are presented as ±SEM. (**** P < 0.0001 vs. WT + vehicle; n = 7/group)