Skip to main content

Table 1 Baseline demographic and disease characteristics

From: Effects of canagliflozin, a sodium glucose co-transporter 2 inhibitor, on blood pressure and markers of arterial stiffness in patients with type 2 diabetes mellitus: a post hoc analysis

 

Pooled, PBO-controlled studies [16]

ABPM study [17]

Characteristica

PBO

(n = 646)

CANA 100 mg

(n = 833)

CANA 300 mg

(n = 834)

PBO

(n = 56)

CANA 100 mg

(n = 57)

CANA 300 mg

(n = 56)

Sex, n (%)

 Male

334 (52)

408 (49)

404 (48)

33 (59)

34 (60)

31 (55)

 Female

312 (48)

425 (51)

430 (52)

23 (41)

23 (40)

25 (45)

Age, years

56.3 (9.8)

55.9 (10.1)

55.7 (9.5)

59.6 (9.5)

57.8 (8.7)

58.3 (6.9)

Race, n (%)b

 White

470 (73)

591 (71)

610 (73)

46 (82)

45 (79)

43 (77)

 Black or African American

28 (4)

43 (5)

48 (6)

9 (16)

10 (18)

12 (21)

 Asian

82 (13)

103 (12)

100 (12)

0

1 (2)

1 (2)

 Otherc

66 (10)

96 (12)

76 (9)

1 (2)

1 (2)

0

HbA1c,  %

8.0 (0.9)

8.0 (0.9)

8.0 (1.0)

8.2 (0.9)

8.1 (0.9)

8.0 (0.8)

BMI, kg/m2

31.9 (6.4)

32.3 (6.4)

32.0 (6.5)

32.9 (5.7)

33.0 (6.0)

34.1 (6.8)

eGFR, mL/min/1.73 m2

87.0 (19.8)

88.3 (19.0)

88.8 (18.9)

87.9 (18.3)

87.2 (20.3)

85.6 (19.7)

Duration of T2DM, years

7.5 (6.2)

7.2 (5.8)

7.4 (6.2)

11.8 (8.7)

9.4 (6.0)

10.3 (6.2)

Seated SBP, mmHg

128.5 (13.2)

128.0 (12.8)

128.8 (12.8)

137.7 (8.6)

138.5 (11.1)

139.2 (8.8)

Seated DBP, mmHg

77.9 (8.3)

77.5 (8.0)

78.2 (8.3)

82.7 (8.6)

82.4 (7.7)

83.0 (8.2)

  1. ABPM ambulatory blood pressure monitoring, BMI body mass index, CANA canagliflozin, DBP diastolic blood pressure, eGFR estimated glomerular filtration rate, PBO placebo, SD standard deviation, SBP systolic blood pressure, T2DM type 2 diabetes mellitus
  2. aData are mean (SD) unless otherwise indicated
  3. bPercentages may not total 100% due to rounding
  4. cIncludes American Indian or Alaska Native, Native Hawaiian or other Pacific Islander, multiple, other, unknown, and not reported in the pooled, PBO-controlled studies; and includes other and unknown in the ABPM study