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Table 5 Overview of trials evaluating long-term outcomes of various DES types in diabetic subpopulation

From: Third generation drug eluting stent (DES) with biodegradable polymer in diabetic patients: 5 years follow-up

(%)

Year

FU

Stent

N of pts DM

MACE

Cardiac death

MI

TVR

TLR

ST

Olesen et al.

2015

5 years

ZES

169

28.4

15

13.6

24.8

18.3

1

   

SES

168

18.5

5

13.6

13.6

8.3

2.3

     

p = 0.032

p < 0.01

p = ns

p < 0.01

p = 0.006

p = 0.02

Billinger et al.

2012

5 years

SES and PES combined

SES (503), PES (509)

25.9 vs. 19.2

11.4 vs. 4.3

6.5 vs. 6.8

 

14.4 vs. 14.1

6 vs. 4.6

     

p = 0.02

p < 0.0001

p = ns

 

p = ns

p = ns

Onuma et al.

2011

5 years

BMS

112

53.6

 

11

   
   

SES

159

40.5

 

4.8

33.2

  
   

CABG

96

23.4

 

5.2

10.7

  
     

p < 0.01

p = ns

p = 0.04

p < 0.001

  

Maeng et al.

2015

4 years

EES

108

20.4

8.3

1.9

12

5.6

0.9

   

SES

105

23.8

4.8

7.6

16.2

9.5

1.9

     

p = 0.55

p = 0.3

p = 0.067

p = 0.39

p = 0.28

p = 0.55

Simsek et al.

2013

3 years

EES

804

18

12

3.1

10.3

5.6

6.8

   

SES

512

21.7

8.4

5.7

17.4

11.5

8.7

   

PES

547

20.6

9.6

7.4

16.8

11.3

10.2

Stiermaier et al.

2014

5 years

SES

120

29.7

7.6

9.3

18.6

15.3

1.6

   

PES

116

31.6

8.8

7.9

23.7

15.8

0.9

     

p = 0.86

p = 0.94

p = 0.88

p = 0.44

p = 1.0

p = 1.0

Sinning et al.

2014

5 years

SES

95

36

15

8

NA

13

5

   

MBS

95

52

13

9

NA

29

6

     

p = 0.02

p = ns

p = ns

 

p = 0.003

p = ns

Sato et al.

2012

5 years

SES DM

85

27.1

2.4

4.7

15.3

9.4

3.5

   

SES non-DM

112

16.1

2.7

0

14.3

8.9

0

     

p = 0.06

p = 0.635

p = 0.827

p = 0.843

p = 0.886

p = 0.883

Park et al.

2012

5 years

SES

3101

17.5 vs. 12.3

1.8 vs. 2.0

6.8 vs. 4.2

9.6 vs. 6.9

8.8 vs. 6.0

2.3 vs. 2.2

   

PES

       
     

p < 0.001

p = 0.623

p < 0.001

p < 0.001

p < 0.001

p = 0.820

Jensen et al.

2015

5 years

EES

194

17

8.2

2.6

 

4.6

2 pts

   

SES

196

26.5

10.2

5.6

 

10.2

5 pts

Vardi et al.

2013

5 years

ZES

268

17.7

3.7

1.3

17.2

11.2

1.2

   

SES and PES

268

26.6

7

5.1

20

12

0.8

     

p = 0.012

p = 0.06

p = 0.011

p = ns

p = ns

p = ns