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Table 2 Correlates of IL-22 levels at baseline (cross-sectional analysis): final model from multivariable linear regression analysis

From: Serum levels of interleukin-22, cardiometabolic risk factors and incident type 2 diabetes: KORA F4/FF4 study

Variable

β (95% CI)

P

Male sex

0.524 (0.401; 0.648)

<0.001

Current smoking

0.439 (0.228; 0.651)

<0.001

Former smoking

0.060 (−0.061; 0.181)

0.332

HDL cholesterol (mmol/l)

−0.172 (−0.337; −0.008)

0.041

eGFR (ml/min per 1.73 m2)

−0.010 (−0.014; −0.007)

<0.001

IL-1RA (pg/ml)

0.001 (0.000; 0.001)

<0.001

  1. Regression coefficients β and corresponding 95% confidence intervals (per given unit in the table) and P values are based on a final model with ln(IL-22) as dependent variable after a forward selection including blocks of independent variables at each step (see below). At each step non-significant variables (P > 0.05) were excluded from further analysis
  2. Step 1 age and sex
  3. Step 2 smoking status, alcohol consumption, physical activity
  4. Step 3 BMI
  5. Step 4 HDL cholesterol, LDL cholesterol, triglycerides, hypertension, history of myocardial infarction, eGFR
  6. Step 5 hsCRP, IL-6, IL-18, TNFα, IL-1RA, sICAM-1, adiponectin
  7. eGFR, estimated glomerular filtration rate; IL-1RA, IL-1 receptor antagonist