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Table 2 Correlations between urinary NAG and carotid IMT and other parameters in T2D (N = 343)

From: The renal tubular damage marker urinary N-acetyl-β-d-glucosaminidase may be more closely associated with early detection of atherosclerosis than the glomerular damage marker albuminuria in patients with type 2 diabetes

Baseline characteristics

Urinary NAG

Mean

IMT

Maximum IMT

Mean of maximum IMT

r

p

r

p

r

p

r

p

Demographics

        

 Age (years)

0.27

<0.001

0.47

<0.001

0.44

<0.001

0.45

<0.001

 BMI (kg/m2)

0.03

0.54

0.08

0.16

0.10

0.06

0.10

0.07

 Waist circumference (cm)

0.09

0.11

0.13

0.01

0.17

0.001

0.17

0.002

 Systolic blood pressure (mmHg)

0.03

0.59

0.09

0.10

0.10

0.06

0.11

0.04

 Diastolic blood pressure (mmHg)

0.002

0.97

−0.24

<0.001

−0.23

<0.001

−0.22

<0.001

 Duration of diabetes (years)

0.20

<0.001

0.11

0.05

0.10

0.06

0.10

0.06

Laboratory indices

        

 HbA1C (%)

0.21

<0.001

0.07

0.19

0.04

0.48

0.05

0.36

 Glycated albumin (%)

0.27

<0.001

0.03

0.61

0.04

0.50

0.04

0.52

 Basal glucose (mg/dl)

0.20

<0.001

0.10

0.06

0.06

0.29

0.07

0.22

 Stimulated glucose (mg/dl)

0.32

<0.001

0.02

0.70

0.07

0.19

0.06

0.30

 Total cholesterol (mg/dl)

0.03

0.56

0.04

0.43

0.02

0.71

0.03

0.58

 Triglyceride (mg/dl)

0.04

0.50

0.04

0.42

0.02

0.77

0.03

0.54

 HDL cholesterol (mg/dl)

−0.14

0.01

−0.16

0.002

−0.15

0.01

−0.16

0.002

 LDL cholesterol (mg/dl)

0.02

0.74

0.04

0.48

0.04

0.51

0.04

0.50

 White blood cell count (103/µl)

0.03

0.70

0.04

0.64

0.12

0.16

0.07

0.44

 Uric acid (mg/dl)

−0.12

0.03

0.08

0.14

0.10

0.07

0.09

0.08

 eGFR CKD-EPI (ml/min/1.73 m2)

−0.22

<0.001

−0.31

<0.001

−0.31

<0.001

−0.30

<0.001

Indices of diabetes complications

        

 Urinary NAG (U/g creatinine)

1

0.10

0.07

0.11

0.04

0.11

0.05

 Urinary NAG, quartile

0.12

0.03

0.13

0.01

0.13

0.02

 Urinary ACR (mg/g creatinine)

0.24

<0.001

0.07

0.19

0.07

0.22

0.08

0.16

 Urinary ACR, quartile

0.23

<0.001

0.05

0.36

0.04

0.48

0.05

0.33

 Mean carotid IMT (mm)

0.10

0.07

1

0.93

<0.001

0.97

<0.001

 Maximum carotid IMT (mm)

0.11

0.04

0.93

<0.001

1

0.97

<0.001

 Mean of maximum carotid IMT (mm)

0.11

0.05

0.97

<0.001

0.97

<0.001

1

  1. NAG N-acetyl-β-d-glucosaminidase, IMT intima-media thickness, T2D type 2 diabetes mellitus, BMI body mass index, HDL high density lipoprotein, LDL low density lipoprotein, eGFR estimated glomerular filtration rate, CKD-EPI chronic kidney disease epidemiology collaboration, ACR albumin-to-creatinine ratio
  2. Bolditalics denotes statistical significance at p < 0.05